In addition to being a component of innate immunity and an ancient defense mechanism
against invading pathogens, complement activation also participates in the adaptive …

The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …

Human epidermal growth factor receptor 2 (HER2) is a receptor tyrosine kinase that plays an
oncogenic role in breast, gastric and other solid tumors. However, anti-HER2 therapies are …

Activation of the complement system is a major pathogenic event that drives various
inflammatory responses in numerous diseases. All pathways of complement activation lead …

Complement is a central part of the immune system that has developed as a first defense
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …

Background Lung cancer is the leading cause of cancer deaths worldwide. New diagnostics
are needed to detect early stage lung cancer because it may be cured with surgery …

Sialic acids represent a family of sugar molecules derived from neuraminic acid that
frequently terminate glycan chains and contribute to many biological processes. Already five …

Recent progressions in immunotherapy have transformed cancer treatment, providing a
promising strategy that activates the immune system of the patient to find and eliminate …

For decades, complement has been recognized as an effector arm of the immune system
that contributes to the destruction of tumor cells. In fact, many therapeutic strategies have …

Colorectal cancer (CRC) is the third most common malignant tumor and the second most
fatal cancer worldwide. Several parts of the immune system contribute to fighting cancer …