Simple Summary The rapidly advancing field of deep learning, specifically transformer-
based architectures and attention mechanisms, has found substantial applicability in …

The identification of FACT as a histone chaperone enabling transcription through chromatin
in vitro has strongly shaped how its roles are envisioned. However, FACT has been …

Silencers are noncoding DNA sequence fragments located on the genome that suppress
gene expression. The variation of silencers in specific cells is closely related to gene …

The mRNA life cycle is a complex biochemical process, involving transcription initiation,
elongation, termination, splicing, and degradation. Each of these molecular events is …

As a simple and programmable nuclease-based genome editing tool, the CRISPR/Cas9
system has been widely used in target-gene repair and gene-expression regulation. The …

Gene expression is dependent on RNA Polymerase II (Pol II) activity in eukaryotes. In
addition to determining the rate of RNA synthesis for all protein coding genes, Pol II serves …

Abstract RNA Polymerase II (Pol II) transcriptional elongation pausing is an integral part of
the dynamic regulation of gene transcription in the genome of metazoans. It plays a pivotal …

Trans-acting splicing factors play a pivotal role in modulating alternative splicing by
specifically binding to cis-elements in pre-mRNAs. There are approximately 1500 RNA …

Abstract Promoter-proximal Polymerase II (Pol II) pausing is a key rate-limiting step for gene
expression. DNA and RNA-binding trans-acting factors regulating the extent of pausing have …

Across all branches of life, transcription elongation is a crucial, regulated phase in gene
expression. Many recent studies in eukaryotes have focused on the regulation of promoter …