Why primate models matter

KA Phillips, KL Bales, JP Capitanio… - American journal of …, 2014 - Wiley Online Library
Research involving nonhuman primates (NHPs) has played a vital role in many of the
medical and scientific advances of the past century. NHPs are used because of their …

Epigenetics and the biological definition of gene× environment interactions

MJ Meaney - Child development, 2010 - Wiley Online Library
Variations in phenotype reflect the influence of environmental conditions during
development on cellular functions, including that of the genome. The recent integration of …

From mice to men: what can we learn about personality from animal research?

SD Gosling - Psychological bulletin, 2001 - psycnet.apa.org
The author explores the viability of a comparative approach to personality research. A
review of the diverse animal-personality literature suggests that (a) most research uses trait …

Genome of the Chinese tree shrew

Y Fan, ZY Huang, CC Cao, CS Chen, YX Chen… - Nature …, 2013 - nature.com
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in
animals used as experimental models in biomedical research. Currently, there are …

Looking on the bright side of serotonin transporter gene variation

JR Homberg, KP Lesch - Biological psychiatry, 2011 - Elsevier
Converging evidence indicates an association of the short (s), low-expressing variant of the
repeat length polymorphism, serotonin transporter-linked polymorphic region (5-HTTLPR) …

Maternal care and the development of stress responses

D Francis, MJ Meaney - 2002 - direct.mit.edu
Stress is a risk factor for a variety of illnesses, ranging from auto-immune disorders to mental
illness. The pathways through which stressful events can promote the development of such …

The developmental origins of anxiety

C Gross, R Hen - Nature Reviews Neuroscience, 2004 - nature.com
Anxiety is a mental state that is elicited in anticipation of threat or potential threat. Sensations
of anxiety are a normal part of human experience, but excessive or inappropriate anxiety …

[HTML][HTML] Serotonin transporter: gene, genetic disorders, and pharmacogenetics

DL Murphy, A Lerner, G Rudnick… - Molecular …, 2004 - triggered.stanford.clockss.org
The highly evolutionarily conserved serotonin transporter (SERT) regulates the entire
serotoninergic system and its receptors via mod-ulation of extracellular fluid serotonin …

Early experience and serotonin transporter gene variation interact to influence primate CNS function

AJ Bennett, KP Lesch, A Heils, JC Long… - Molecular …, 2002 - nature.com
Nonhuman primates offer unique opportunities to study the effects of genes, environments,
and their interaction, on physiology and complex behavior. We examined genotype and …

Impulsivity, aggression, and serotonin: a molecular psychobiological perspective

KP Lesch, U Merschdorf - Behavioral sciences & the law, 2000 - Wiley Online Library
The expression of aggressiveness, which constitutes many facets of behavior, is influenced
by a complex interaction of biologic, psychologic, and social variables. Even though …