(CVD) in individuals with type 1 diabetes mellitus (T1DM), the pathophysiology underlying
the relationship between cardiovascular events, CVD risk factors, and T1DM is not well …

Type 1 diabetes mellitus (T1DM) is associated with premature cardiovascular disease
(CVD), but the underlying mechanisms remain poorly understood. The American Diabetes …

OBJECTIVE Early initiation of intensive diabetes therapy aimed at achieving near-normal
glycemia reduces the early development of vascular complications in type 1 diabetes. We …

The American Diabetes Association 2020 Standards of Medical Care in Diabetes
(Standards of Care) recommends a hemoglobin A1c (A1C) of< 7%(53 mmol/mol) for many …

The presence of cardiovascular disease (CVD) in Type 1 diabetes largely impairs life
expectancy. Hyperglycemia leading to an increase in oxidative stress is considered to be the …

Peripheral hyperinsulinemia resulting from subcutaneous insulin injection is associated with
metabolic defects that include abnormal glucose metabolism. The first aim of this study was …

Endogenous insulin secretion exposes the liver to three times higher insulin concentrations
than the rest of the body. Because subcutaneous insulin delivery eliminates this gradient …

The prevalence of atherosclerotic cardiovascular disease is higher in patients with type 2
diabetes, a disorder characterized by hyperinsulinemia and insulin resistance. The role of …

The intraperitoneal route of administration accounts for less than 1% of insulin treatment
regimes in patients with diabetes mellitus type 1 (DM1). Despite being used for decades, a …

Purpose of review Type 1 diabetes mellitus (T1DM) is associated with increased mortality,
with premature cardiovascular disease (CVD) a major factor. To date, research has …