Single-cell RNA sequencing (scRNA-seq) allows researchers to collect large catalogues
detailing the transcriptomes of individual cells. Unsupervised clustering is of central …

The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

To examine global changes in breast heterogeneity across different states, we determined
the single‐cell transcriptomes of> 340,000 cells encompassing normal breast, preneoplastic …

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …

Spatial transcriptomics data can provide high-throughput gene expression profiling and the
spatial structure of tissues simultaneously. Most studies have relied on only the gene …

Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to
subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …

The upper airway epithelium, which is mainly composed of multiciliated, goblet, club and
basal cells, ensures proper mucociliary function and can regenerate in response to assaults …

Glandular epithelia, including the mammary and prostate glands, are composed of basal
cells (BCs) and luminal cells (LCs),. Many glandular epithelia develop from multipotent …

Aging is closely associated with increased susceptibility to breast cancer, yet there have
been limited systematic studies of aging-induced alterations in the mammary gland. Here …