Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver disease in developed
countries. Its frequency is increasing in the general population mostly due to the widespread …

Anti-epileptic drugs (AEDs) are an important group of drugs of several generations, ranging
from the oldest phenobarbital (1912) to the most recent cenobamate (2019). Cannabidiol …

Read-across approaches often remain inconclusive as they do not provide sufficient
evidence on a common mode of action across the category members. This read-across case …

Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs, as VPA-induced
hepatotoxicity is one of the most severe adverse reaction that can lead to death. The …

Drug development is currently hampered by the inability of animal experiments to accurately
predict human response. While emerging organ on chip technology offers to reduce risk …

Valproic acid is a frequently used antiepileptic drug and known pediatric hepatotoxic agent.
In search of pharmaceuticals with increased effectiveness and reduced toxicity, analogue …

Epilepsy in children is the most frequent, heterogeneous and difficult to classify chronic
neurologic condition with the etiology found in 35–40% of patients. Our aim is to detect the …

Non-alcoholic fatty liver disease is a major cause of chronic liver pathology in humans. Fatty
liver disease involves the accumulation of hepatocellular fat in hepatocytes that can …

Farnesoid X receptor (FXR), or NR1H4, protects the liver from insults of various etiologies. A
role of FXR in drug-induced liver injury has also been hypothesized yet only marginally …

Introduction. Valproic acid is a medication most commonly used in the treatment of
emotional and neurological depression, psychological imbalances, epilepsy, and bipolar …