Teleost fish are more diverse than any other vertebrate group, and yet only a limited number
of species are fished and farmed globally. Efforts to expand the quantity and diversity of fish …

Ethanol exposure during gestation is an early life stressor that profoundly dysregulates
structure and functions of the embryonal nervous system, altering the cognitive and …

BACKGROUND: Neurons containing proopiomelanocortin (POMC)-derived peptides, known
to control stress axis, metabolic, and immune functions, have a lower function in patients …

Proopiomelanocortin (POMC) is a key mediator of satiety. Epigenetic marks such as DNA
methylation may modulate POMC expression and provide a biological link between early life …

Following the cloning of the melanocortin receptor and agouti protein genes, a model was
developed for the central melanocortin system with respect to the regulation of energy and …

Expression of the pro-opiomelanocortin (POMC) gene integrates numerous inputs that
reflect the developmental history of POMC-expressing cells of the pituitary and …

Context: Cushing disease, due to pituitary corticotroph tumor ACTH hypersecretion, drives
excess adrenal cortisol production with adverse morbidity and mortality. Loss of …

Pituitary melanotroph and corticotroph cells produce and secrete peptides from the
multifunctional precursor protein proopiomelanocortin (POMC). Stimulation of the secretory …

Alcohol exposure during fetal and early postnatal development can lead to an increased
incidence of later life adult‐onset diseases. Examples include central nervous system …

Human-directed domestication of terrestrial animals traditionally requires thousands of years
for breeding. The most prominent behavioral features of domesticated animals include …