Human rhinoviruses (RVs) are picornaviruses that can cause a variety of illnesses including
the common cold, lower respiratory tract illnesses such as bronchitis and pneumonia, and …

Asthma is a chronic inflammatory disease of the airways in which the majority of patients
respond to treatment with corticosteroids and β2-adrenoceptor agonists. Acute …

Activation of the inflammasome is a key function of the innate immune response that
regulates inflammation in response to microbial substances. Inflammasome activation by …

Background Human rhinovirus (HRV) infection is a major trigger for asthma exacerbations.
Anti-viral immunity appears to be abnormal in asthma, with immune dysfunction reported in …

Background We have shown that rhinovirus, a cause of asthma exacerbation, colocalizes
with CD68+ and CD11b+ airway macrophages after experimental infection in human …

Human rhinovirus (RV) is the major cause of common cold, and it also plays a significant
role in asthma and asthma exacerbation. The airway epithelium is the primary site of RV …

Background Children with risk alleles at the 17q21 genetic locus who wheeze during
rhinovirus illnesses have a greatly increased likelihood of developing childhood asthma. In …

Human rhinoviruses (RV) are a frequent cause of respiratory tract infections with substantial
morbidity and mortality in some patients. Nevertheless, the genetic basis of susceptibility to …

Infections with rhinovirus (RV) cause asthma exacerbations. Recent studies suggest that
macrophages play a role in asthmatic airway inflammation and the innate immune response …

Asthma exacerbations are often caused by rhinovirus (RV). We and others have shown that
Toll-like receptor 2 (TLR2), a membrane surface receptor that recognizes bacterial …