Mitochondria in health, disease, and aging
JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …
The pathogenesis of Parkinson's disease
Parkinson's disease is a progressive neurodegenerative condition associated with the
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …
[HTML][HTML] Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy
C Chu, X Wang, C Yang, F Chen, L Shi, W Xu, K Wang… - Redox Biology, 2023 - Elsevier
Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a
primary catalyst for microcirculation dysfunction and enterogenous infection. Previous …
primary catalyst for microcirculation dysfunction and enterogenous infection. Previous …
Subcellular visualization: organelle-specific targeted drug delivery and discovery
X Shao, C Meng, W Song, T Zhang, Q Chen - Advanced Drug Delivery …, 2023 - Elsevier
Organelles perform critical biological functions due to their distinct molecular composition
and internal environment. Disorders in organelles or their interacting networks have been …
and internal environment. Disorders in organelles or their interacting networks have been …
Tom20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress
MA Eldeeb, AN Bayne, A Fallahi… - Proceedings of the …, 2024 - National Acad Sciences
Mutations in PTEN-induced putative kinase 1 (PINK1) cause autosomal recessive early-
onset Parkinson's disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial …
onset Parkinson's disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial …
NADPH and mitochondrial quality control as targets for a circadian-based fasting and exercise therapy for the treatment of Parkinson's disease
WM Curtis, WA Seeds, MP Mattson, PC Bradshaw - Cells, 2022 - mdpi.com
Dysfunctional mitochondrial quality control (MQC) is implicated in the pathogenesis of
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …
Parkinson's disease (PD). The improper selection of mitochondria for mitophagy increases …
CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy
Y Zhou, Y Liu, Z Kang, H Yao, N Song, M Wang… - Autophagy, 2023 - Taylor & Francis
Despite growing evidence that has declared the importance of circRNAs in
neurodegenerative diseases, the clinical significance of circRNAs in dopaminergic (DA) …
neurodegenerative diseases, the clinical significance of circRNAs in dopaminergic (DA) …
The relationship of alpha-synuclein to mitochondrial dynamics and quality control
NJ Thorne, DA Tumbarello - Frontiers in molecular neuroscience, 2022 - frontiersin.org
Maintenance of mitochondrial health is essential for neuronal survival and relies upon
dynamic changes in the mitochondrial network and effective mitochondrial quality control …
dynamic changes in the mitochondrial network and effective mitochondrial quality control …
Crosstalk between autophagy and CSCs: molecular mechanisms and translational implications
D Li, X Peng, G He, J Liu, X Li, W Lin, J Fang, X Li… - Cell Death & …, 2023 - nature.com
Cancer stem cells (CSCs) play a key role in regulating tumorigenesis, progression, as well
as recurrence, and possess typical metabolic characteristics. Autophagy is a catabolic …
as recurrence, and possess typical metabolic characteristics. Autophagy is a catabolic …
Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products
K Yang, L Zeng, J Zeng, Y Deng, S Wang, H Xu… - Ageing Research …, 2023 - Elsevier
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder of the
central nervous system after Alzheimer's disease. The current understanding of PD focuses …
central nervous system after Alzheimer's disease. The current understanding of PD focuses …