Tick-borne encephalitis (TBE) is an illness caused by tick-borne encephalitis virus (TBEV)
infection which is often limited to a febrile illness, but may lead to very aggressive …

In 1935, the olfactory route was hypothesized to be a portal for virus entry into the central
nervous system (CNS). This hypothesis was based on experiments in which nasophayngeal …

Background Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese
encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents …

The innate immune system is the host's first line of defense against the invasion of
pathogens including flavivirus. The programmed cell death controlled by genes plays an …

Flaviviruses are major emerging human pathogens on a global scale. Some flaviviruses can
infect the central nervous system of the host and therefore are regarded as neurotropic. The …

Members of the Flaviviridae family are posing a significant threat to human health
worldwide. Many flaviviruses are capable of inducing severe inflammation in humans …

Background Tick-borne encephalitis (TBE) is a severe neuropathological disorder caused
by tick-borne encephalitis virus (TBEV). Brain TBEV infection is characterized by extensive …

Background Flaviviruses are a group of diverse and emerging arboviruses and an immense
global health problem. A number of flaviviruses are neurotropic, causing severe encephalitis …

Background Tick-borne encephalitis virus (TBEV) is a member of the Flaviviridae family,
Flavivirus genus, which includes several important human pathogens. It is responsible for …

Tick-borne encephalitis virus (TBEV) may cause tick-borne encephalitis (TBE), a potential
life-threatening infection of the central nervous system in humans. Phylogenetically, TBEVs …