Prostaglandins (PGs) are multifunctional regulators of bone metabolism that stimulate both
bone resorption and formation. PGs have been implicated in bone resorption associated …

The present review aims to systematically and critically analyze the current knowledge on
phospholipases and their role in physiological and pathological mineralization undertaken …

Cystic fibrosis (CF)-related bone disease has emerged as a significant comorbidity of CF
and is characterized by decreased bone formation and increased bone resorption. Both …

Increases in local and systemic bone resorption are hallmarks of rheumatoid arthritis (RA).
Osteoclasts are implicated in these processes and their enhanced differentiation may …

Osteoclasts play a critical role in both normal bone metabolism and bone resorption in the
joints of patients with rheumatoid arthritis. It has been reported that non-steroidal anti …

We recently showed that human osteoblasts synthesize prostaglandin D2 (PGD2) and
express both DP and CRTH2 receptors. Activation of the DP receptor decreased …

In a recent study we have shown that prostaglandin D 2 (PGD 2) induces human osteoclast
(OC) apoptosis through the activation of the chemoattractant receptor homologous molecule …

Prostaglandin D2 (PGD2) is a lipid mediator synthesized from arachidonic acid that directly
activates two specific receptors, the D-type prostanoid (DP) receptor and chemoattractant …

Objective. To test the hypothesis that increased concentrations of prostaglandin D2 (PGD2)
correlate with bone remodeling. Studies using isolated bone cells indicate that PGD2 may …

We previously reported that the ability of continuously elevated PTH to stimulate osteoblastic
differentiation in bone marrow stromal cell cultures was abrogated by an osteoclastic factor …