Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors
for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological …

Hemolytic diseases are associated with elevated levels of circulating free heme that can
mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly …

The pandemic of the coronavirus disease 2019 (COVID-19) has become a global public
health crisis. The symptoms of COVID-19 range from mild to severe, but the physiological …

Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and,
most importantly, hydrogen peroxide. However, it is unclear whether accumulation of …

Many mammals risk damage from oxidative stress stemming from frequent dives (ie, cycles
of ischemia/reperfusion and hypoxia/reoxygenation), high altitude and subterranean …

Global warming and plastic pollution are among the most important environmental problems
today. Unfortunately, our world is warming more than expected and biological life, especially …

Reperfusion injury follows ischemia/reperfusion events occurring during myocardial
infarction, stroke, embolism, and other peripheral vascular diseases. Decreased blood flow …

The improvement in childhood cancer treatments resulted in a marked improvement in the
survival of pediatric cancer patients. However, as survival increased, it was also possible to …

Serum uric acid (SUA) has garnered an increased interest in recent years as an important
determinant of cardiovascular disease. Uric acid, a degradation product of purine …

Cetacea, whales, dolphins and porpoises form an order of mammals adapted to aquatic life.
Their transition to an aquatic habitat resulted in exceptional protection against cellular …