Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …
Signaling pathways and intervention therapies in sepsis
Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …
systemic inflammatory and immune response to infection. Over decades, advanced …
Exercise plasma boosts memory and dampens brain inflammation via clusterin
Z De Miguel, N Khoury, MJ Betley, B Lehallier… - Nature, 2021 - nature.com
Physical exercise is generally beneficial to all aspects of human and animal health, slowing
cognitive ageing and neurodegeneration. The cognitive benefits of physical exercise are …
cognitive ageing and neurodegeneration. The cognitive benefits of physical exercise are …
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
JC Holter, SE Pischke, E de Boer… - Proceedings of the …, 2020 - National Acad Sciences
Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic is hypothesized to be driven by an overreacting innate immune response, where …
pandemic is hypothesized to be driven by an overreacting innate immune response, where …
Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
J Yu, X Yuan, H Chen, S Chaturvedi… - Blood, The Journal …, 2020 - ashpublications.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious
respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial …
respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial …
Shattering barriers toward clinically meaningful MSC therapies
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …
Defining blood-induced microglia functions in neurodegeneration through multiomic profiling
Blood protein extravasation through a disrupted blood–brain barrier and innate immune
activation are hallmarks of neurological diseases and emerging therapeutic targets …
activation are hallmarks of neurological diseases and emerging therapeutic targets …
Endothelial dysfunction and immunothrombosis in sepsis
E Maneta, E Aivalioti, S Tual-Chalot… - Frontiers in …, 2023 - frontiersin.org
Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …
Intravascular mesenchymal stromal/stem cell therapy product diversification: time for new clinical guidelines
Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …
NETosis, complement, and coagulation: a triangular relationship
CM de Bont, WC Boelens, GJM Pruijn - Cellular & molecular …, 2019 - nature.com
NETosis is a regulated form of neutrophil cell death that contributes to the host defense
against pathogens and was linked to various diseases soon after its first description in 2004 …
against pathogens and was linked to various diseases soon after its first description in 2004 …