As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age …

Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

Mechanical forces play critical roles in the function of living cells. However, the underlying
mechanisms of how forces influence nuclear events remain elusive. Here, we show that …

The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …

The cell nucleus must continually resist and respond to intercellular and intracellular
mechanical forces to transduce mechanical signals and maintain proper genome …

Introduction Tissues can be soft like brain, bone marrow, and fat, which bear little
mechanical stress, or stiff like muscle, cartilage, and bone, which sustain high levels of …