Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

Classification and comparison of small RNAs from plants

MJ Axtell - Annual review of plant biology, 2013 - annualreviews.org
Regulatory small RNAs, which range in size from 20 to 24 nucleotides, are ubiquitous
components of endogenous plant transcriptomes, as well as common responses to …

Identification of some Echinophora platyloba miRNAs using computational methods and the effect of these miRNAs in the expression of TLN2 and ZNF521 genes in …

S Sasani, S Rashidi Monfared… - Cellular, Molecular and …, 2024 - cmbr-journal.com
MicroRNAs (miRNAs) are small (~ 22 nucleotides) non-coding endogenous RNA molecules
that negatively regulate gene expression at the post-transcriptional level by degrading the …

[HTML][HTML] Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry

P Wang, Y Zhou, AM Richards - Theranostics, 2021 - ncbi.nlm.nih.gov
The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …

[HTML][HTML] MicroRNAs: synthesis, mechanism, function, and recent clinical trials

F Wahid, A Shehzad, T Khan, YY Kim - Biochimica et Biophysica Acta (BBA …, 2010 - Elsevier
MicroRNAs (miRNAs) are a class of small, endogenous RNAs of 21–25 nucleotides (nts) in
length. They play an important regulatory role in animals and plants by targeting specific …

Genome sequencing and analysis of the model grass Brachypodium distachyon

DNA sequencing and assembly Barry Kerrie 5 Lucas … - Nature, 2010 - nature.com
Three subfamilies of grasses, the Ehrhartoideae, Panicoideae and Pooideae, provide the
bulk of human nutrition and are poised to become major sources of renewable energy. Here …

[HTML][HTML] MicroRNAs: genomics, biogenesis, mechanism, and function

DP Bartel - cell, 2004 - cell.com
MicroRNAs (miRNAs) are endogenous∼ 22 nt RNAs that can play important regulatory
roles in animals and plants by targeting mRNAs for cleavage or translational repression …

The nuclear RNase III Drosha initiates microRNA processing

Y Lee, C Ahn, J Han, H Choi, J Kim, J Yim, J Lee… - Nature, 2003 - nature.com
Hundreds of small RNAs of∼ 22 nucleotides, collectively named microRNAs (miRNAs),
have been discovered recently in animals and plants,,,,,,,,,. Although their functions are …

Small silencing RNAs: an expanding universe

M Ghildiyal, PD Zamore - Nature reviews genetics, 2009 - nature.com
Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA
classes have been identified, including microRNAs (miRNAs), small interfering RNAs …

Human microRNA targets

B John, AJ Enright, A Aravin, T Tuschl, C Sander… - PLoS …, 2004 - journals.plos.org
MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the
message or inhibit translation. The specific function of most mammalian miRNAs is …