Over the past year, numerous studies in the peer reviewed and preprint literature have
reported on the virological, epidemiological and clinical characteristics of the coronavirus …

Human leukocyte antigen class I (HLA-I) molecules are encoded by major histocompatibility
complex (MHC) class I loci in humans. The binding and interaction between HLA-I …

Abstract Human Leukocyte Antigen (HLA) includes a large set of genes with important
actions in immune response against viral infection. Numerous studies have revealed the …

The ability of mammals to mount adaptive immune responses culminating with the
establishment of immunological memory is predicated on the ability of the mature T cell …

Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the
vertebrate adaptive immune response by presenting peptide antigens on the cell surface …

The human leukocyte antigen (HLA)-bound viral antigens serve as an immunological
signature that can be selectively recognized by T cells. As viruses evolve by acquiring …

Neoepitopes arising from amino acid substitutions due to single nucleotide polymorphisms
are targets of T cell immune responses to cancer and are of significant interest in the …

T cells play a crucial role in controlling and driving the immune response with their ability to
discriminate peptides derived from healthy as well as pathogenic proteins. In this review, we …

Identification of CD8+ T cell epitopes is critical for the development of immunotherapeutics.
Existing methods for major histocompatibility complex class I (MHC class I) ligand discovery …

The development of immunological therapies that incorporate peptide antigens presented to
T cells by MHC proteins is a long sought-after goal, particularly for cancer, where mutated …