Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …

Children born to mothers, with or at risk, of human immunodeficiency virus type-1 (HIV-1)
infection are on the rise due to affordable access of antiretroviral therapy (ART) to pregnant …

Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects
consisting in the failure of the neural tube to form and close. The mechanisms underlying …

Background Due to the critical role of folates in neurodevelopment, it is important to
understand potential interactions between anti-HIV drugs used during pregnancy, and folate …

Function of the mature central nervous system (CNS) requires a substantial proportion of the
body's energy consumption. During development, the CNS anlage must maintain its …

Progress in medicine allows for a better understanding of the purpose of dietary components
in prophylaxis of civilization diseases and suggests that alimentation not only supplies …

In recent years, chitosan has gained considerable attention due to its favorable properties
such as excellent biocompatibility and biodegradability for which it can be used as a health …

Neuropathic pain affects 7–10% of the population and is often ineffectively and incompletely
treated. Although the gold standard for treatment of neuropathic pain includes tricyclic …

The SLC25A32 dysfunction is associated with neural tube defects (NTDs) and exercise
intolerance, but very little is known about disease-specific mechanisms due to a paucity of …

Neural tube defects (NTDs) are a group of common and severe congenital malformations.
The PI3K-AKT signalling pathway plays a crucial role in the neural tube development. There …