The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …

Rats and mice are used for studying neuronal circuits underlying recognition memory due to
their ability to spontaneously remember the occurrence of an object, its place and an …

The entorhinal cortex is one of the first regions to exhibit neurodegeneration in Alzheimer's
disease, and as such identification of entorhinal cortex dysfunction may aid detection of the …

Rats and mice have been demonstrated to show episodic-like memory, a prototype of
episodic memory, as defined by an integrated memory of the experience of an object or …

How the topography of neural circuits relates to their function remains unclear. Although
topographic maps exist for sensory and motor variables, they are rarely observed for …

Path integration (PI) is impaired early in Alzheimer's disease (AD) but reflects multiple sub-
processes that may be differentially sensitive to AD. To characterize these sub-processes …

Hippocampal place cells are spatially tuned neurons that serve as elements of a 'cognitive
map'in the mammalian brain. To detect the animal's location, place cells are thought to rely …

Layer II of the medial entorhinal cortex (MEC) contains two principal cell types: pyramidal
cells and stellate cells. Accumulating evidence suggests that these two cell types have …

Path integration is a straightforward concept with varied connotations that are important to
different disciplines concerned with navigation, such as ethology, cognitive science, robotics …

Place and grid cells in the hippocampal formation provide foundational representations of
environmental location, and potentially of locations within conceptual spaces. Some …