Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

A large body of epidemiologic evidence has linked insufficient sleep duration and quality to
the risk of obesity, insulin resistance and type 2 diabetes. To address putative causal …

Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus
(T2DM) remain two major challenges for public health systems globally. In the past 9 years …

The pineal hormone melatonin has attracted great scientific interest since its discovery in
1958. Despite the enormous number of basic and clinical studies the exact role of melatonin …

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues
and cells. It acts via G protein-coupled receptors expressed in various areas of the central …

The past decade has witnessed a revival of interest in the hormone melatonin, partly
attributable to the discovery that genetic variation in MTNR1B–the melatonin receptor gene …

Sleep disturbances, including sleep insufficiency and sleep fragmentation, have been linked
to abnormal glucose metabolism and increased diabetes risk. Well‐controlled laboratory …

Evidence is accumulating regarding the importance of circadian core oscillators, several
associated factors, and melatonin signaling in the maintenance of health. Dysfunction of …

Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …

Glaucoma is a progressive optic neuropathy associated with damage to retinal ganglion
cells (RGCs) and disrupted circadian rhythms. Melatonin is a promising substance to …