Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

Blocked cellular differentiation is a central pathologic feature of the myeloid malignancies,
myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Treatment regimens …

The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising
therapies entering clinical translation, yet patient responses remain heterogeneous, and …

Abstract Micro-/nanoplastics (MNPLs), novel environmental pollutants, widely exist in the
environment and life and bring health risks. Previous studies have shown that NMPLs can …

Lineage-ambiguous leukemias are high-risk malignancies of poorly understood genetic
basis. Here, we describe a distinct subgroup of acute leukemia with expression of myeloid, T …

Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy
haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic …

Mitochondria are key regulators of hematopoietic stem cell (HSC) homeostasis. Our
research identifies the transcription factor Nynrin as a crucial regulator of HSC maintenance …

Although the importance of genome organization for transcriptional regulation of cell-fate
decisions and function is clear, the changes in chromatin architecture and how these impact …

Transposable elements hold regulatory functions that impact cell fate determination by
controlling gene expression. However, little is known about the transcriptional machinery …

In the past decade, remarkable progress in cancer medicine has been achieved by the
development of treatments that target DNA sequence variants. However, a purely genetic …