Neutrophils are implicated in almost every stage of oncogenesis and paradoxically display
anti-and pro-tumor properties. Accumulating evidence indicates that neutrophils display …

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm which results in
clonal proliferation of abnormally differentiated hematopoietic cells. In this review …

While the catalog of mammalian transcripts and their expression levels in different cell types
and disease states is rapidly expanding, our understanding of transcript function lags …

Excitatory neurotransmission and its activity-dependent plasticity are largely determined by
AMPA-receptors (AMPARs), ion channel complexes whose cell physiology is encoded by …

Objective Early detection and treatment are particularly important to epithelial ovarian
cancer (EOC). Studies have shown that circular RNA (circRNA) dysregulation is associated …

Summary Plasma membrane Ca 2+-ATPases (PMCAs), a family of P-type ATPases, extrude
Ca 2+ ions from the cytosol to the extracellular space and are considered to be key …

CCAAT/enhancer binding protein α (C/EBPα) dimerizes via its leucine zipper (LZ) domain to
bind DNA via its basic region and activate transcription via N-terminal trans-activation …

Mutation or epigenetic silencing of the transcription factor C/EBPα is observed in∼ 10% of
patients with acute myeloid leukemia (AML). In both cases, a common global gene …

The integrated stress response (ISR) controls cellular adaptations to nutrient deprivation,
redox imbalances, and endoplasmic reticulum (ER) stress. ISR genes are upregulated in …

The process of blood formation, haematopoiesis, depends upon a small number of
haematopoietic stem cells (HSCs) that reside in the bone marrow. Differentiation of HSCs is …