Metabolic signaling in T cells
The maintenance of organismal homeostasis requires partitioning and transport of
biochemical molecules between organ systems, their composite cells, and subcellular …
biochemical molecules between organ systems, their composite cells, and subcellular …
Alzheimer's disease risk genes and mechanisms of disease pathogenesis
We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in
AD pathogenesis. More recent advances in understanding of the human genome …
AD pathogenesis. More recent advances in understanding of the human genome …
Sex differences in brain protein expression and disease
Most complex human traits differ by sex, but we have limited insight into the underlying
mechanisms. Here, we investigated the influence of biological sex on protein expression …
mechanisms. Here, we investigated the influence of biological sex on protein expression …
Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers
The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …
Microglial priming in neurodegenerative disease
VH Perry, C Holmes - Nature Reviews Neurology, 2014 - nature.com
Under physiological conditions, the number and function of microglia—the resident
macrophages of the CNS—is tightly controlled by the local microenvironment. In response to …
macrophages of the CNS—is tightly controlled by the local microenvironment. In response to …
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
M Mittelbrunn, C Gutiérrez-Vázquez… - Nature …, 2011 - nature.com
The immune synapse is an exquisitely evolved means of communication between T cells
and antigen-presenting cells (APCs) during antigen recognition. Recent evidence points to …
and antigen-presenting cells (APCs) during antigen recognition. Recent evidence points to …
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's …
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's …
Alzheimer's disease genetics: from the bench to the clinic
Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a
strong genetic component. Several genes have been associated with AD risk for nearly 20 …
strong genetic component. Several genes have been associated with AD risk for nearly 20 …
The immunological synapse: a molecular machine controlling T cell activation
The specialized junction between a T lymphocyte and an antigen-presenting cell, the
immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring …
immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring …
Cell biology of the glomerular podocyte
H Pavenstadt, W Kriz, M Kretzler - Physiological reviews, 2003 - journals.physiology.org
Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …
most prominent features are interdigitated foot processes with filtration slits in between …