The maintenance of organismal homeostasis requires partitioning and transport of
biochemical molecules between organ systems, their composite cells, and subcellular …

We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in
AD pathogenesis. More recent advances in understanding of the human genome …

Most complex human traits differ by sex, but we have limited insight into the underlying
mechanisms. Here, we investigated the influence of biological sex on protein expression …

The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …

Under physiological conditions, the number and function of microglia—the resident
macrophages of the CNS—is tightly controlled by the local microenvironment. In response to …

The immune synapse is an exquisitely evolved means of communication between T cells
and antigen-presenting cells (APCs) during antigen recognition. Recent evidence points to …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's …

Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a
strong genetic component. Several genes have been associated with AD risk for nearly 20 …

The specialized junction between a T lymphocyte and an antigen-presenting cell, the
immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …