Viruses and intracellular bacterial pathogens (IBPs) have in common the need of suitable
host cells for efficient replication and proliferation during infection. In human infections, the …

The ecosystem of the gut microbiota consists of diverse intestinal species with multiple
metabolic and immunologic activities and it is closely connected with the intestinal epithelia …

Viral oncogenesis is a multistep process largely depending on the complex interplay
between viruses and host factors. The oncoviruses are capable of subverting the cell …

SGT-53 is a novel investigational agent that comprises an immunoliposome carrying a
plasmid vector driving expression of the human TP53 gene that encodes wild-type human …

This review based on translational research predicts that the transcription factor p53 is the
key effector of all anti-acne therapies. All-trans retinoic acid (ATRA) and isotretinoin (13-cis …

Ubiquitination is a post-translational modification regulating critical cellular processes such
as protein degradation, trafficking and signaling pathways, including activation of the innate …

Influenza is a highly infectious disease caused by three types of viruses, including influenza
A virus (IAV), influenza B virus, and, rarely, influenza C virus. IAV is a major, global public …

Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving
non-malignant cells unharmed. With the first US Food and Drug Administration-approved …

Rift Valley fever virus (RVFV) is an emerging viral zoonosis that is responsible for
devastating outbreaks among livestock and is capable of causing potentially fatal disease in …

Abstract Purpose of Review This review aims to elucidate the multifaceted role of the tumor
suppressor protein p53 in the context of HIV infection. We explore how p53, a pivotal …