Increasing evidence that several drug compounds exert their effects through interactions
with multiple targets is boosting the development of research fields that challenge the data …

This review seeks to provide a timely survey of the scope and limitations of cheminformatics
methods in natural product‐based drug discovery. Following an overview of data resources …

Understanding of the capacity of the natural world to produce secondary metabolites is
important to a broad range of fields, including drug discovery, ecology, biosynthesis, and …

An intermolecular, photocatalytic dicarbofunctionalization (DCF) of olefins enabled by the
merger of Giese-type addition with Ni/photoredox dual catalysis has been realized …

Background Natural products have been an important source of lead compounds for drug
discovery. How to find and evaluate bioactive natural products is critical to the achievement …

Because of their unique effects and relatively low side effects, herbal medicine has been
gaining popularity all over the world. Quality control is a challenge to ensure safety, efficacy …

Natural products remain one of the most productive sources of chemical inspiration for the
development of new drugs. The structures of more than 250 000 natural products are …

Highlights•Molecular complexity is used in lead optimization, library design and compound
selection.•Complexity as an intuitive concept but not easy to quantify in a unique …

For millennia, numerous cultures and civilizations have relied on traditional remedies
derived from plants to treat a wide range of conditions and ailments. Here, we systematically …

Matching the power of high throughput screening to the chemical diversity of natural products -
Natural Product Reports (RSC Publishing) DOI:10.1039/C3NP70052F Royal Society of …