The impact of host genetic variation on infection with HIV-1
PJ McLaren, M Carrington - Nature immunology, 2015 - nature.com
The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a
complex phenotype determined by interactions among the pathogen, the human host and …
complex phenotype determined by interactions among the pathogen, the human host and …
HIV-1 adaptation to HLA: a window into virus–host immune interactions
HIV-1 develops specific mutations within its genome that allow it to escape detection by
human leukocyte antigen (HLA) class I-restricted immune responses, notably those of CD8+ …
human leukocyte antigen (HLA) class I-restricted immune responses, notably those of CD8+ …
Selection bias at the heterosexual HIV-1 transmission bottleneck
JM Carlson, M Schaefer, DC Monaco, R Batorsky… - Science, 2014 - science.org
Introduction Heterosexual HIV-1 transmission is an inefficient process with rates reported at<
1% per unprotected sexual exposure. When transmission occurs, systemic infection is …
1% per unprotected sexual exposure. When transmission occurs, systemic infection is …
Impact of pre-adapted HIV transmission
Human leukocyte antigen class I (HLA)-restricted CD8+ T lymphocyte (CTL) responses are
crucial to HIV-1 control. Although HIV can evade these responses, the longer-term impact of …
crucial to HIV-1 control. Although HIV can evade these responses, the longer-term impact of …
Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence
It is widely believed that epidemics in new hosts diminish in virulence over time, with natural
selection favoring pathogens that cause minimal disease. However, a tradeoff frequently …
selection favoring pathogens that cause minimal disease. However, a tradeoff frequently …
Variation in HIV-1 Nef function within and among viral subtypes reveals genetically separable antagonism of SERINC3 and SERINC5
HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our
understanding of how naturally occurring global Nef sequence diversity impacts these …
understanding of how naturally occurring global Nef sequence diversity impacts these …
Role of HLA adaptation in HIV evolution
Killing of HIV-infected cells by CD8+ T-cells imposes strong selection pressure on the virus
toward escape. The HLA class I molecules that are successful in mediating some degree of …
toward escape. The HLA class I molecules that are successful in mediating some degree of …
Analysis of mycotoxin and secondary metabolites in commercial and traditional Slovak cheese samples
Cheese represents a dairy product extremely inclined to fungal growth and mycotoxin
production. The growth of fungi belonging to Aspergillus, Penicillium, Fusarium, Claviceps …
production. The growth of fungi belonging to Aspergillus, Penicillium, Fusarium, Claviceps …
Subtype‐independent near full‐length HIV‐1 genome sequencing and assembly to be used in large molecular epidemiological studies and clinical management
Abstract Introduction: HIV-1 near full-length genome (HIV-NFLG) sequencing from plasma is
an attractive multidimensional tool to apply in large-scale population-based molecular …
an attractive multidimensional tool to apply in large-scale population-based molecular …
HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control
J Arora, PJ McLaren, N Chaturvedi… - Proceedings of the …, 2019 - National Acad Sciences
Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I
molecules has repeatedly been associated with HIV-1 control and progression to AIDS …
molecules has repeatedly been associated with HIV-1 control and progression to AIDS …