Fluorescence has long been recognized as a powerful tool for probing biological structure
and function. Nearly sixty-five years ago, Coons and colleagues introduced the first …

The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase
that triggers the degradation of multiple substrates during mitosis. Cdc20/Fizzy and …

Production of functional eggs requires meiosis to be coordinated with developmental
signals. Oocytes arrest in prophase I to permit oocyte differentiation, and in most animals, a …

Mammalian oocytes begin meiosis in the fetal ovary, but only complete it when fertilized in
the adult reproductive tract. This review examines the cell biology of this protracted process …

Meiotic cell cycle in mammalian oocytes is a dynamic process that involves several stop/go
channels. The cell cycle arrest in oocyte occurs at various stages such as diplotene …

In mammalian oocytes DNA damage can cause chromosomal abnormalities that potentially
lead to infertility and developmental disorders. However, there is little known about the …

Mammalian oocytes arrest at prophase of meiosis I at around birth and they remain arrested
at this stage until puberty when the preovulatory surge of luteinizing hormone (LH) causes …

Oocyte maturation in mouse is associated with a dramatic reorganisation of the endoplasmic
reticulum (ER) from a network of cytoplasmic accumulations in the germinal vesicle-stage …

Mammalian oocytes are arrested at prophase I until puberty when luteinizing hormone (LH)
induces resumption of meiosis of follicle-enclosed oocytes. Resumption of meiosis is tightly …

Vertebrate oocytes face a particular challenge concerning the regulation of gene expression
during meiotic maturation. Global transcription becomes quiescent in fully grown oocytes …