Specialized roles of neurofilament proteins in synapses: Relevance to neuropsychiatric disorders
Neurofilaments are uniquely complex among classes of intermediate filaments in being
composed of four subunits (NFL, NFM, NFH and alpha-internexin in the CNS) that differ in …
composed of four subunits (NFL, NFM, NFH and alpha-internexin in the CNS) that differ in …
Intermediate filaments in developing neurons: Beyond structure
CJ Bott, B Winckler - Cytoskeleton, 2020 - Wiley Online Library
Neuronal development relies on a highly choreographed progression of dynamic cellular
processes by which newborn neurons migrate, extend axons and dendrites, innervate their …
processes by which newborn neurons migrate, extend axons and dendrites, innervate their …
A novel human CAMK2A mutation disrupts dendritic morphology and synaptic transmission, and causes ASD-related behaviors
Characterizing the functional impact of novel mutations linked to autism spectrum disorder
(ASD) provides a deeper mechanistic understanding of the underlying pathophysiological …
(ASD) provides a deeper mechanistic understanding of the underlying pathophysiological …
Quantitative proteomics analysis of CaMKII phosphorylation and the CaMKII interactome in the mouse forebrain
AJ Baucum, BC Shonesy, KL Rose… - ACS chemical …, 2015 - ACS Publications
Ca2+/calmodulin-dependent protein kinase IIα (CaMKIIα) autophosphorylation at Thr286
and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is …
and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is …
CaMKII enhances voltage-gated sodium channel Nav1. 6 activity and neuronal excitability
AS Zybura, AJ Baucum, AM Rush, TR Cummins… - Journal of Biological …, 2020 - ASBMB
Nav1. 6 is the primary voltage-gated sodium channel isoform expressed in mature axon
initial segments and nodes, making it critical for initiation and propagation of neuronal …
initial segments and nodes, making it critical for initiation and propagation of neuronal …
Regulation of synaptic transmission and plasticity by protein phosphatase 1
Protein phosphatases, by counteracting protein kinases, regulate the reversible
phosphorylation of many substrates involved in synaptic plasticity, a cellular model for …
phosphorylation of many substrates involved in synaptic plasticity, a cellular model for …
Generation and behavior characterization of CaMKIIβ knockout mice
The calcium/calmodulin-dependent protein kinase II (CaMKII) is abundant in the brain,
where it makes important contributions to synaptic organization and homeostasis, including …
where it makes important contributions to synaptic organization and homeostasis, including …
Substrate-selective and calcium-independent activation of CaMKII by α-actinin
N Jalan-Sakrikar, RK Bartlett, AJ Baucum… - Journal of Biological …, 2012 - ASBMB
Protein-protein interactions are thought to modulate the efficiency and specificity of Ca
2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) signaling in specific subcellular …
2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) signaling in specific subcellular …
Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is abundant in striatal medium spiny
neurons (MSNs). CaMKII is dynamically regulated by changes in dopamine signaling, as …
neurons (MSNs). CaMKII is dynamically regulated by changes in dopamine signaling, as …
Spinophilin regulates phosphorylation and interactions of the GluN2B subunit of the N‐methyl‐d‐aspartate receptor
AB Salek, MC Edler, JP McBride… - Journal of …, 2019 - Wiley Online Library
N‐methyl‐d‐Aspartate receptors (NMDARs) are abundant postsynaptic proteins that are
critical for normal synaptic communication. NMDAR channel function is regulated by multiple …
critical for normal synaptic communication. NMDAR channel function is regulated by multiple …