Spinal cord repair: advances in biology and technology

G Courtine, MV Sofroniew - Nature medicine, 2019 - nature.com
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …

[HTML][HTML] Neurostimulation for stroke rehabilitation

WKC Ting, FAR Fadul, S Fecteau… - Frontiers in neuroscience, 2021 - frontiersin.org
Neurological injuries such as strokes can lead to important loss in motor function. Thanks to
neuronal plasticity, some of the lost functionality may be recovered over time. However, the …

An intracortical neuroprosthesis immediately alleviates walking deficits and improves recovery of leg control after spinal cord injury

M Bonizzato, M Martinez - Science translational medicine, 2021 - science.org
Most rehabilitation interventions after spinal cord injury (SCI) only target the sublesional
spinal networks, peripheral nerves, and muscles. However, mammalian locomotion is not a …

Repetitive transcranial magnetic stimulation of the brain after ischemic stroke: mechanisms from animal models

Y Xing, Y Zhang, C Li, L Luo, Y Hua, J Hu… - Cellular and Molecular …, 2023 - Springer
Stroke is a common cerebrovascular disease with high morbidity, mortality, and disability
worldwide. Post-stroke dysfunction is related to the death of neurons and impairment of …

[HTML][HTML] Functional electrical stimulation and the modulation of the axon regeneration program

JS Jara, S Agger, ER Hollis - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Neural injury in mammals often leads to persistent functional deficits as spontaneous repair
in the peripheral nervous system (PNS) is often incomplete, while endogenous repair …

[HTML][HTML] Transspinal stimulation increases motoneuron output of multiple segments in human spinal cord injury

LM Murray, M Knikou - PloS one, 2019 - journals.plos.org
Targeted neuromodulation strategies that strengthen neuronal activity are in great need for
restoring sensorimotor function after chronic spinal cord injury (SCI). In this study, we …

[HTML][HTML] Neurophysiological changes after paired brain and spinal cord stimulation coupled with locomotor training in human spinal cord injury

TS Pulverenti, M Zaaya, M Grabowski… - Frontiers in …, 2021 - frontiersin.org
Neurophysiological changes that involve activity-dependent neuroplasticity mechanisms via
repeated stimulation and locomotor training are not commonly employed in research even …

Brain and spinal cord paired stimulation coupled with locomotor training affects polysynaptic flexion reflex circuits in human spinal cord injury

TS Pulverenti, M Zaaya, M Knikou - Experimental brain research, 2022 - Springer
Neurorecovery from locomotor training is well established in human spinal cord injury (SCI).
However, neurorecovery resulting from combined interventions has not been widely studied …

[HTML][HTML] Brain and spinal cord paired stimulation coupled with locomotor training facilitates motor output in human spinal cord injury

TS Pulverenti, M Zaaya, E Grabowski… - Frontiers in …, 2022 - frontiersin.org
Combined interventions for neuromodulation leading to neurorecovery have gained great
attention by researchers to resemble clinical rehabilitation approaches. In this randomized …

[HTML][HTML] Using EMG to deliver lumbar dynamic electrical stimulation to facilitate cortico-spinal excitability

G Taccola, P Gad, S Culaclii, RM Ichiyama, W Liu… - Brain Stimulation, 2020 - Elsevier
Background Potentiation of synaptic activity in spinal networks is reflected in the magnitude
of modulation of motor responses evoked by spinal and cortical input. After spinal cord …