miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis

CE Condrat, DC Thompson, MG Barbu, OL Bugnar… - Cells, 2020 - mdpi.com
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

Systemic inflammation in traumatic spinal cord injury

O Bloom, PE Herman, AM Spungen - Experimental neurology, 2020 - Elsevier
There are 17,730 new cases of spinal cord injury annually in the United States and up to 2.5
million individuals estimated to be living with chronic spinal cord injury (SCI)(Herman and …

Pathophysiology, classification and comorbidities after traumatic spinal cord injury

J Guest, N Datta, G Jimsheleishvili… - Journal of personalized …, 2022 - mdpi.com
The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …

Bone marrow mesenchymal stem cell-derived exosomal microRNA-125a promotes M2 macrophage polarization in spinal cord injury by downregulating IRF5

Q Chang, Y Hao, Y Wang, Y Zhou, H Zhuo… - Brain Research Bulletin, 2021 - Elsevier
Background Spinal cord injury (SCI) may cause loss of locomotor function, and macrophage
is a major cell type in response to SCI with M1-and M2-phenotypes. The protective role of …

Diagnostic blood RNA profiles for human acute spinal cord injury

N Kyritsis, A Torres-Espín, PG Schupp… - Journal of Experimental …, 2021 - rupress.org
Diagnosis of spinal cord injury (SCI) severity at the ultra-acute stage is of great importance
for emergency clinical care of patients as well as for potential enrollment into clinical trials …

[HTML][HTML] Cerebrospinal fluid (CSF) analysis and interpretation in neurocritical care for acute neurological conditions

AP Hrishi, M Sethuraman - Indian journal of critical care medicine …, 2019 - ncbi.nlm.nih.gov
Cerebrospinal fluid (CSF) is a clear fluid circulating in the intracranial and spinal
compartments. Under normal conditions, the composition of CSF remains constant …

MiRNAs as promising translational strategies for neuronal repair and regeneration in spinal cord injury

S Silvestro, E Mazzon - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) represents a devastating injury to the central nervous system (CNS)
that is responsible for impaired mobility and sensory function in SCI patients. The hallmarks …

[HTML][HTML] Cerebrospinal fluid-derived extracellular vesicles after spinal cord injury promote vascular regeneration via PI3K/AKT signaling pathway

C Li, T Qin, Y Jin, J Hu, F Yuan, Y Cao… - Journal of Orthopaedic …, 2023 - Elsevier
Background The cerebrospinal fluid (CSF), which surrounds the brain and spinal cord, is
predominantly produced by the choroid plexus of the ventricle. Although CSF-derived …

MicroRNA‐22‐3p alleviates spinal cord ischemia/reperfusion injury by modulating M2 macrophage polarization via IRF5

H Fang, M Yang, Q Pan, HL Jin, HF Li… - Journal of …, 2021 - Wiley Online Library
Cell death after spinal cord ischemia/reperfusion (I/R) can occur through necrosis,
apoptosis, and autophagy, resulting in changes to the immune environment. However, the …

Circulating microRNA expression signatures accurately discriminate myalgic encephalomyelitis from fibromyalgia and comorbid conditions

E Nepotchatykh, I Caraus, W Elremaly, C Leveau… - Scientific Reports, 2023 - nature.com
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and fibromyalgia (FM) are
two chronic complex diseases with overlapping symptoms affecting multiple systems and …