Abstract The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR)
signaling pathway is important in a variety of biological activities, including cellular …

This article recapitulates the evidence on the role of mammalian targets of rapamycin
(mTOR) complex pathways in multiple sclerosis (MS). Key biological processes that intersect …

Autophagy modulation is considered to be a promising programmed cell death mechanism
to prevent and cure a great number of disorders and diseases. The crucial step in designing …

Multiple sclerosis (MS) is an autoimmune and chronic inflammatory demyelinating disease
of the central nervous system (CNS), which gives rise to focal lesion in CNS and cause …

During the past few decades, considerable efforts have been made to discover and validate
new molecular mechanisms and biomarkers of neurodegenerative diseases. Recent …

The accumulation of senescent cells within tissues is a hallmark of the aging process.
Senescent cells are also commonly present in many age-related diseases and in the cancer …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS). Our research aimed to find an immunomodulatory therapy for MS. An …

Background Immune homeostasis requires fully functional Tregs with a stable phenotype to
control autoimmunity. Although IL‐34 is a cytokine first described as mainly involved in …

Clinical symptom worsening in patients with multiple sclerosis (MS) is driven by
inflammation compartmentalized within the CNS, which results in chronic neuronal damage …

Metabolomics-based technologies map in vivo biochemical changes that may be used as
early indicators of pathological abnormalities prior to the development of clinical symptoms …