Advances in pathogenesis, progression, potential targets and targeted therapeutic strategies in SARS-CoV-2-Induced COVID-19

H Zhou, WJ Ni, W Huang, Z Wang, M Cai… - Frontiers in …, 2022 - frontiersin.org
As the new year of 2020 approaches, an acute respiratory disease quietly caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus …

Gas6/TAM axis involvement in modulating inflammation and fibrosis in COVID-19 patients

M Rizzi, S Tonello, D D'Onghia… - International Journal of …, 2023 - mdpi.com
Gas6 (growth arrest-specific gene 6) is a widely expressed vitamin K-dependent protein that
is involved in many biological processes such as homeostatic regulation, inflammation and …

Phosphatidylserine receptors enhance SARS-CoV-2 infection

D Bohan, H Van Ert, N Ruggio, KJ Rogers… - PLoS …, 2021 - journals.plos.org
Phosphatidylserine (PS) receptors enhance infection of many enveloped viruses through
virion-associated PS binding that is termed apoptotic mimicry. Here we show that this …

The association of low vitamin K status with mortality in a cohort of 138 hospitalized patients with COVID-19

A Linneberg, FB Kampmann, SB Israelsen… - Nutrients, 2021 - mdpi.com
It has recently been hypothesized that vitamin K could play a role in COVID-19. We aimed to
test the hypotheses that low vitamin K status is a common characteristic of patients …

Baseline Plasma Gas6 Protein Elevation Predicts Adverse Outcomes in Hospitalized COVID‐19 Patients

S Tonello, M Rizzi, E Matino, M Costanzo… - Disease …, 2022 - Wiley Online Library
Reliable biomarkers allowing early patients' stratification for the risk of adverse outcomes in
COVID‐19 are lacking. Gas6, together with its tyrosine kinase receptors named TAM, is …

COVID-19 biomarkers at the crossroad between patient stratification and targeted therapy: the role of validated and proposed parameters

M Rizzi, D D'Onghia, S Tonello, R Minisini… - International Journal of …, 2023 - mdpi.com
Clinical knowledge about SARS-CoV-2 infection mechanisms and COVID-19
pathophysiology have enormously increased during the pandemic. Nevertheless, because …

Acute bone loss following SARS‐CoV‐2 infection in mice

AK Haudenschild, BA Christiansen… - Journal of …, 2023 - Wiley Online Library
The novel coronavirus disease 2019 (COVID‐19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) and has infected more than 650 million people …

Human milk inhibits some enveloped virus infections, including SARS-CoV-2, in an intestinal model

I Aknouch, A Sridhar, E Freeze… - Life Science …, 2022 - life-science-alliance.org
Human milk is important for antimicrobial defense in infants and has well demonstrated
antiviral activity. We evaluated the protective ability of human milk against severe acute …

New avenues to explore in SARS-CoV-2 infection: both TRIM25 and TRIM56 positively correlate with VEGF, GAS6, and sAXL in COVID-19 patients

G Baskol, M Özel, H Saracoglu, B Ulger… - Viral …, 2022 - liebertpub.com
The ongoing COVID-19 pandemic poses a significant threat to human health. Many
hypotheses regarding pathogenesis have been proposed and are being tried to be clarified …

[HTML][HTML] GAS6/TAM axis as therapeutic target in liver diseases

A Tutusaus, A Morales, PG de Frutos… - Seminars in Liver …, 2024 - thieme-connect.com
TAM (TYRO3, AXL, and MERTK) protein tyrosine kinase membrane receptors and their
vitamin K-dependent ligands GAS6 and protein S (PROS) are well-known players in tumor …