Abstract The multifunctional Survival Motor Neuron (SMN) protein is required for the survival
of all organisms of the animal kingdom. SMN impacts various aspects of RNA metabolism …

Abstract mRNA is packaged into ribonucleoprotein particles called mRNPs. A multitude of
RNA-binding proteins as well as a host of associated proteins participate in the fate of …

Abstract Box C/D and H/ACA RNPs are essential ribonucleoprotein particles that are found
throughout both eukaryotes [small nucleolar RNPs (snoRNPs)] and archaea [snoRNP‐like …

The function of human nervous system is critically dependent on proper interneuronal
communication. Exosomes and other extracellular vesicles are emerging as a novel form of …

Motor neuron diseases are neurological disorders characterized primarily by the
degeneration of spinal motor neurons, skeletal muscle atrophy, and debilitating and often …

At the post-transcriptional level, expression of protein-coding genes is controlled by a series
of RNA regulatory events including nuclear processing of primary transcripts, transport of …

Alternative pre-mRNA splicing (AS) provides the potential to produce diversity at RNA and
protein levels. Disruptions in the regulation of pre-mRNA splicing can lead to diseases. With …

Modifications in cellular RNAs have emerged as key regulators of all aspects of gene
expression, including pre-mRNA splicing. During spliceosome assembly and function, the …

Liquid–liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving
force underlying the formation of membrane-less organelles. Such biomolecular …

Transcription in the nucleus of animal cells is performed by three distinct RNA polymerases
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …