[HTML][HTML] Gut microbiome and health: mechanistic insights

WM De Vos, H Tilg, M Van Hul, PD Cani - Gut, 2022 - gut.bmj.com
The gut microbiota is now considered as one of the key elements contributing to the
regulation of host health. Virtually all our body sites are colonised by microbes suggesting …

Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Dietary lipids, gut microbiota and lipid metabolism

M Schoeler, R Caesar - Reviews in endocrine and metabolic disorders, 2019 - Springer
The gut microbiota is a central regulator of host metabolism. The composition and function of
the gut microbiota is dynamic and affected by diet properties such as the amount and …

The intestinal microbiota fuelling metabolic inflammation

H Tilg, N Zmora, TE Adolph, E Elinav - Nature Reviews Immunology, 2020 - nature.com
Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

How probiotics affect the microbiota

G Wieërs, L Belkhir, R Enaud, S Leclercq… - Frontiers in cellular …, 2020 - frontiersin.org
Probiotics have been used to treat a variety of diseases for decades; however, what is the
rationale for their application? Such a treatment was first proposed in the early nineteenth …

[HTML][HTML] Human gut microbiome: hopes, threats and promises

PD Cani - Gut, 2018 - gut.bmj.com
The microbiome has received increasing attention over the last 15 years. Although gut
microbes have been explored for several decades, investigations of the role of …

Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation

T Sang, C Guo, D Guo, J Wu, Y Wang, Y Wang… - Carbohydrate …, 2021 - Elsevier
Ganoderma lucidum has been shown to have anti-obesity effects. However, polysaccharide
extracted from the sporoderm-broken spores of Ganoderma lucidum (BSGLP) against …

New approaches and challenges to targeting the endocannabinoid system

V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

H Plovier, A Everard, C Druart, C Depommier… - Nature medicine, 2017 - nature.com
Obesity and type 2 diabetes are associated with low-grade inflammation and specific
changes in gut microbiota composition,,,,,,. We previously demonstrated that administration …

Gut microbiota as a trigger for metabolic inflammation in obesity and type 2 diabetes

TPM Scheithauer, E Rampanelli, M Nieuwdorp… - Frontiers in …, 2020 - frontiersin.org
The gut microbiota has been linked to the development of obesity and type 2 diabetes (T2D).
The underlying mechanisms as to how intestinal microbiota may contribute to T2D are only …