Manganese in health and disease
Manganese is an important metal for human health, being absolutely necessary for
development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or …
development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or …
The transition metals copper and iron in neurodegenerative diseases
Neurodegenerative diseases constitute a worldwide health problem. Metals like iron and
copper are essential for life, but they are also involved in several neurodegenerative …
copper are essential for life, but they are also involved in several neurodegenerative …
Ascorbic acid treatment, similarly to fluoxetine, reverses depressive-like behavior and brain oxidative damage induced by chronic unpredictable stress
M Moretti, A Colla, G de Oliveira Balen… - Journal of psychiatric …, 2012 - Elsevier
Reactive oxygen species (ROS) have been shown to play a role in the pathophysiology of
depression. Taking into account that experimental chronic unpredictable stress (CUS) …
depression. Taking into account that experimental chronic unpredictable stress (CUS) …
Elevated manganese and cognitive performance in school-aged children and their mothers
JA Menezes-Filho, CO Novaes, JC Moreira… - Environmental …, 2011 - Elsevier
BACKGROUND: Growing evidence suggests that excess manganese (Mn) in children is
associated with neurobehavioral impairments. In Brazil, elevated hair Mn concentrations …
associated with neurobehavioral impairments. In Brazil, elevated hair Mn concentrations …
Redox imbalance
D Berg, MBH Youdim, P Riederer - Cell and tissue research, 2004 - Springer
Substantial evidence implies that redox imbalance attributable to an overproduction of
reactive oxygen species or reactive nitrogen species that overwhelm the protective defense …
reactive oxygen species or reactive nitrogen species that overwhelm the protective defense …
Extracellular dopamine potentiates Mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3–dependent manner in …
A Benedetto, C Au, DS Avila, D Milatovic… - PLoS genetics, 2010 - journals.plos.org
Parkinson's disease (PD)-mimicking drugs and pesticides, and more recently PD-associated
gene mutations, have been studied in cell cultures and mammalian models to decipher the …
gene mutations, have been studied in cell cultures and mammalian models to decipher the …
Akt phosphorylates NQO1 and triggers its degradation, abolishing its antioxidative activities in Parkinson's disease
The oxidative metabolism of dopamine and consequent oxidative stress are implicated in
dopaminergic neuronal loss, mediating the pathogenesis of Parkinson's disease (PD). The …
dopaminergic neuronal loss, mediating the pathogenesis of Parkinson's disease (PD). The …
Expression of NAD (P) H: quinone oxidoreductase in the normal and Parkinsonian substantia nigra
FL Van Muiswinkel, RAI De Vos, J Bol, G Andringa… - Neurobiology of …, 2004 - Elsevier
Dopamine (DA) autooxidation, and consequent formation of neurotoxic DA-derived
quinones and reactive oxygen species, has been implicated in dopaminergic cell death and …
quinones and reactive oxygen species, has been implicated in dopaminergic cell death and …
Oxidation chemistry of catecholamines and neuronal degeneration: an update
A Napolitano, P Manini… - Current medicinal …, 2011 - ingentaconnect.com
Aberrant oxidative pathways of catecholamine neurotransmitters, ie dopamine and
norepinephrine, are an important biochemical correlate of catecholaminergic neuron loss in …
norepinephrine, are an important biochemical correlate of catecholaminergic neuron loss in …
Gut microbiota as a potential player in Mn-induced neurotoxicity
Manganese (Mn) is an essential metal, which at high exposures causes neurotoxic effects
and neurodegeneration. The neurotoxic effects of Mn are mediated by neuroinflammation …
and neurodegeneration. The neurotoxic effects of Mn are mediated by neuroinflammation …