[HTML][HTML] Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
H Steiner, A Fukumori, S Tagami, M Okochi - Cell Stress, 2018 - ncbi.nlm.nih.gov
Alzheimers disease (AD) is a devastating neurodegenerative disease of the elderly
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …
Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond
B De Strooper… - Annual review of …, 2015 - annualreviews.org
γ-Secretases are a group of widely expressed, intramembrane-cleaving proteases involved
in many physiological processes. Their clinical relevance comes from their involvement in …
in many physiological processes. Their clinical relevance comes from their involvement in …
Substrate recruitment of γ‐secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping
A Fukumori, H Steiner - The EMBO journal, 2016 - embopress.org
Intramembrane proteases execute fundamental biological processes ranging from crucial
signaling events to general membrane proteostasis. Despite the availability of structural …
signaling events to general membrane proteostasis. Despite the availability of structural …
Generating conformation-specific synthetic antibodies to trap proteins in selected functional states
A set of phage display sorting strategies and validation methodologies are presented that
are capable of producing high performance synthetic antibodies (sABs) with customized …
are capable of producing high performance synthetic antibodies (sABs) with customized …
[HTML][HTML] Complex regulation of γ-secretase: from obligatory to modulatory subunits
N Gertsik, D Chiu, YM Li - Frontiers in aging neuroscience, 2015 - frontiersin.org
γ-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid
precursor protein (APP), catalyzing the formation of amyloid beta (Aβ) peptides that form …
precursor protein (APP), catalyzing the formation of amyloid beta (Aβ) peptides that form …
Physiological and pathological roles of the γ-secretase complex
CM Carroll, YM Li - Brain research bulletin, 2016 - Elsevier
Gamma-secretase (GS) is an enzyme complex that cleaves numerous substrates, and it is
best known for cleaving amyloid precursor protein (APP) to form amyloid-beta (Aβ) peptides …
best known for cleaving amyloid precursor protein (APP) to form amyloid-beta (Aβ) peptides …
[HTML][HTML] Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme
Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two
diabetes, Alzheimer's, inflammation, and other human diseases. However, the process …
diabetes, Alzheimer's, inflammation, and other human diseases. However, the process …
The dynamic conformational landscape of γ-secretase
N Elad, B De Strooper, S Lismont… - Journal of cell …, 2015 - journals.biologists.com
The structure and function of the γ-secretase proteases are of great interest because of their
crucial roles in cellular and disease processes. We established a novel purification protocol …
crucial roles in cellular and disease processes. We established a novel purification protocol …
Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme
LA McCord, WG Liang, E Dowdell… - Proceedings of the …, 2013 - National Acad Sciences
Insulin-degrading enzyme (IDE) selectively degrades the monomer of amyloidogenic
peptides and contributes to clearance of amyloid β (Aβ). Thus, IDE retards the progression of …
peptides and contributes to clearance of amyloid β (Aβ). Thus, IDE retards the progression of …
Recombinant antibodies to histone post-translational modifications
T Hattori, JM Taft, KM Swist, H Luo, H Witt, M Slattery… - Nature …, 2013 - nature.com
Variability in the quality of antibodies to histone post-translational modifications (PTMs) is a
widely recognized hindrance in epigenetics research. Here, we produced recombinant …
widely recognized hindrance in epigenetics research. Here, we produced recombinant …