Alzheimers disease (AD) is a devastating neurodegenerative disease of the elderly
population. Genetic evidence strongly suggests that aberrant generation and/or clearance of …

γ-Secretases are a group of widely expressed, intramembrane-cleaving proteases involved
in many physiological processes. Their clinical relevance comes from their involvement in …

Intramembrane proteases execute fundamental biological processes ranging from crucial
signaling events to general membrane proteostasis. Despite the availability of structural …

A set of phage display sorting strategies and validation methodologies are presented that
are capable of producing high performance synthetic antibodies (sABs) with customized …

γ-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid
precursor protein (APP), catalyzing the formation of amyloid beta (Aβ) peptides that form …

Gamma-secretase (GS) is an enzyme complex that cleaves numerous substrates, and it is
best known for cleaving amyloid precursor protein (APP) to form amyloid-beta (Aβ) peptides …

Insulin degrading enzyme (IDE) plays key roles in degrading peptides vital in type two
diabetes, Alzheimer's, inflammation, and other human diseases. However, the process …

The structure and function of the γ-secretase proteases are of great interest because of their
crucial roles in cellular and disease processes. We established a novel purification protocol …

Insulin-degrading enzyme (IDE) selectively degrades the monomer of amyloidogenic
peptides and contributes to clearance of amyloid β (Aβ). Thus, IDE retards the progression of …

Variability in the quality of antibodies to histone post-translational modifications (PTMs) is a
widely recognized hindrance in epigenetics research. Here, we produced recombinant …