The balance between stem cell potency and lineage specification entails the integration of
both extrinsic and intrinsic cues, which ultimately influence gene expression through the …

MITF governs multiple steps in the development of melanocytes, including specification from
neural crest, growth, survival, and terminal differentiation. In addition, the level of MITF …

Rationale: Mitochondrial dysfunction facilitates heart failure development forming a
therapeutic target, but the mechanism involved remains unclear. We studied whether the …

How genetic information is modified to generate phenotypic variation within a species is one
of the central questions in evolutionary biology. Here we focus on the striking intraspecific …

The intrinsic drivers of migration in glioblastoma (GBM) are poorly understood. To better
capture the native molecular imprint of GBM and its developmental context, here we isolate …

TEA domain transcription factor 4 (TEAD4) is an important member of the TEAD family. As a
downstream effector of the Hippo pathway, TEAD4 has essential roles in cell proliferation …

Background: Congenital heart disease (CHD)—structural abnormalities of the heart that
arise during embryonic development—is the most common inborn malformation, affecting≤ …

The neural crest (NC) is an embryonic cell population that contributes to key vertebrate-
specific features including the craniofacial skeleton and peripheral nervous system. Here we …

Objective Visceral obesity contributes to obesity‐related complications; however, the
intrinsic mechanism of depot‐specific adipose tissue behavior remains unclear. Despite the …

Gastrointestinal stromal tumors (GIST) carrying the D842V activating mutation in the platelet-
derived growth factor receptor alpha (PDGFRA) gene are a very rare subgroup of GIST …