[HTML][HTML] Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role
KS Crider, TP Yang, RJ Berry, LB Bailey - Advances in nutrition, 2012 - Elsevier
ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …
regulation and development. The vitamin folate is a key source of the one carbon group …
Advanced cell culture techniques for cancer drug discovery
CJ Lovitt, TB Shelper, VM Avery - Biology, 2014 - mdpi.com
Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
LE Reinius, N Acevedo, M Joerink, G Pershagen… - PloS one, 2012 - journals.plos.org
Methylation of cytosines at CpG sites is a common epigenetic DNA modification that can be
measured by a large number of methods, now even in a genome-wide manner for hundreds …
measured by a large number of methods, now even in a genome-wide manner for hundreds …
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation
Smoking is a major risk factor in many diseases. Genome wide association studies have
linked genes for nicotine dependence and smoking behavior to increased risk of …
linked genes for nicotine dependence and smoking behavior to increased risk of …
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
Epigenetic control of gene transcription is critical for normal human development and
cellular differentiation. While alterations of epigenetic marks such as DNA methylation have …
cellular differentiation. While alterations of epigenetic marks such as DNA methylation have …
Decline in genomic DNA methylation through aging in a cohort of elderly subjects
Loss of genomic DNA methylation has been found in a variety of common human age-
related diseases. Whether DNA methylation decreases over time as individuals age is …
related diseases. Whether DNA methylation decreases over time as individuals age is …
Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood
FF Zhang, R Cardarelli, J Carroll, KG Fulda, M Kaur… - Epigenetics, 2011 - Taylor & Francis
Reduced levels of global DNA methylation are associated with genomic instability and are
independent predictors of cancer risk. Little is known about the environmental determinants …
independent predictors of cancer risk. Little is known about the environmental determinants …
Ischemic heart disease and stroke in relation to blood DNA methylation
Background: Epigenetic features such as DNA hypomethylation have been associated with
conditions related to cardiovascular risk. We evaluated whether lower blood DNA …
conditions related to cardiovascular risk. We evaluated whether lower blood DNA …
Cigarette smoking behaviors and time since quitting are associated with differential DNA methylation across the human genome
The impact of cigarette smoking can persist for extended periods following smoking
cessation and may involve epigenetic reprogramming. Changes in DNA methylation …
cessation and may involve epigenetic reprogramming. Changes in DNA methylation …
DNA methylation in white blood cells: association with risk factors in epidemiologic studies
Alterations in DNA methylation patterns, both at specific loci and overall in the genome, have
been associated with many different health outcomes. In cancer and other diseases, most of …
been associated with many different health outcomes. In cancer and other diseases, most of …