Reproducible, scalable, and shareable analysis pipelines with bioinformatics workflow managers

L Wratten, A Wilm, J Göke - Nature methods, 2021 - nature.com
The rapid growth of high-throughput technologies has transformed biomedical research.
With the increasing amount and complexity of data, scalability and reproducibility have …

Multi-omics data integration, interpretation, and its application

I Subramanian, S Verma, S Kumar… - … and biology insights, 2020 - journals.sagepub.com
To study complex biological processes holistically, it is imperative to take an integrative
approach that combines multi-omics data to highlight the interrelationships of the involved …

g: Profiler—interoperable web service for functional enrichment analysis and gene identifier mapping (2023 update)

L Kolberg, U Raudvere, I Kuzmin, P Adler… - Nucleic acids …, 2023 - academic.oup.com
Abstract g: Profiler is a reliable and up-to-date functional enrichment analysis tool that
supports various evidence types, identifier types and organisms. The toolset integrates many …

[HTML][HTML] Sustainable data analysis with Snakemake

F Mölder, KP Jablonski, B Letcher, MB Hall… - …, 2021 - ncbi.nlm.nih.gov
Data analysis often entails a multitude of heterogeneous steps, from the application of
various command line tools to the usage of scripting languages like R or Python for the …

Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine

O Mossad, B Batut, B Yilmaz, N Dokalis, C Mezö… - Nature …, 2022 - nature.com
Microglial function declines during aging. The interaction of microglia with the gut microbiota
has been well characterized during development and adulthood but not in aging. Here, we …

[HTML][HTML] gprofiler2--an R package for gene list functional enrichment analysis and namespace conversion toolset g: Profiler

L Kolberg, U Raudvere, I Kuzmin, J Vilo… - …, 2020 - ncbi.nlm.nih.gov
Abstract g: Profiler (https://biit. cs. ut. ee/gprofiler) is a widely used gene list functional
profiling and namespace conversion toolset that has been contributing to reproducible …

Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

A Eskenazi, C Lood, J Wubbolts, M Hites… - Nature …, 2022 - nature.com
A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella
pneumoniae infection after long-term (> 700 days) antibiotic therapy is treated with a pre …

IQ-TREE 2: new models and efficient methods for phylogenetic inference in the genomic era

BQ Minh, HA Schmidt, O Chernomor… - Molecular biology …, 2020 - academic.oup.com
Abstract IQ-TREE (http://www. iqtree. org, last accessed February 6, 2020) is a user-friendly
and widely used software package for phylogenetic inference using maximum likelihood …

[HTML][HTML] Reconstruction of ancient microbial genomes from the human gut

MC Wibowo, Z Yang, M Borry, A Hübner, KD Huang… - Nature, 2021 - nature.com
Loss of gut microbial diversity,,,,–in industrial populations is associated with chronic
diseases, underscoring the importance of studying our ancestral gut microbiome. However …

g: Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

U Raudvere, L Kolberg, I Kuzmin, T Arak… - Nucleic acids …, 2019 - academic.oup.com
Biological data analysis often deals with lists of genes arising from various studies. The g:
Profiler toolset is widely used for finding biological categories enriched in gene lists …