The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

Advances in our understanding of molecular mechanisms of tumorigenesis have translated
into knowledge-based therapies directed against specific oncogenic signaling targets …

The liver is the largest solid organ in the body and is critical for metabolic and immune
functions. However, little is known about the cells that make up the human liver and its …

The mammalian liver possesses a remarkable regenerative ability. Two modes of damage
response have been described:(1) The" oval cell" response emanates from the biliary tree …

Polyploidy, resulting from the duplication of the entire genome of an organism or cell, greatly
affects genes and genomes, cells and tissues, organisms, and even entire ecosystems …

In contrast to all other organs, liver‐to‐body‐weight ratio needs to be maintained always at
100% of what is required for body homeostasis. Adjustment of liver size to 100% of what is …

The source of new hepatocytes in the uninjured liver has remained an open question. By
lineage tracing using the Wnt-responsive gene Axin2 in mice, we identify a population of …

CRISPR–Cas9 technology has revolutionized genome editing and is applicable to the
organoid field. However, precise integration of exogenous DNA sequences into human …

Dividing cells that experience chromosome mis-segregation generate aneuploid daughter
cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes …

Since the detection of cell‐free DNA (cfDNA) in human plasma in 1948, it has been
investigated as a non‐invasive screening tool for many diseases, especially solid tumours …