Simple Summary Vimentin is an important filamentous protein providing structural and
functional support to the cell. During initial stages of cancer development, vimentin …

The receptor tyrosine kinase AXL, activated by a complex interaction between its ligand
growth arrest-specific protein 6 and phosphatidylserine, regulates various vital cellular …

Many signaling pathways are dysregulated in cancer cells and the host tumor
microenvironment. Aberrant receptor tyrosine kinase (RTK) pathways promote cancer …

This comprehensive review explores vimentin as a pivotal therapeutic target in cancer
treatment, with a primary focus on mitigating metastasis and overcoming drug resistance …

Abstract Purpose of Review The AXL signaling pathway is associated with tumor growth as
well as poor prognosis in cancer. Here, we highlight recent strategies for targeting AXL in …

A mesenchymal tumor phenotype associates with immunotherapy resistance, although the
mechanism is unclear. Here, we identified FBXO7 as a maintenance regulator of …

HER2 is a driver in solid tumors, mainly breast, oesophageal and gastric cancer, through
activation of oncogenic signaling pathways such as PI3K or MAPK. HER2 overexpression …

Early cancer recurrence, driven by resistance to therapeutics, is a major obstacle to
overcome poor survival in triple negative breast cancer (TNBC). Recently, overexpression of …

Background Heightened signaling by mesenchymal epithelial transition factor (MET) is
implicated in tumorigenesis. Glesatinib is an investigational, oral inhibitor of MET and AXL …

Deregulation and activation of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian (or
mechanistic) target of rapamycin (mTOR) pathway have a major role in proliferation and cell …