During the last century, there has been an increasing prevalence of hyperuricaemia noted in
many populations. While uric acid is usually discussed in the context of gout …

Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors
for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome; its rising prevalence parallels the rise in obesity and diabetes. Historically …

The exposure of cells, tissues and extracellular matrix to harmful reactive species causes a
cascade of reactions and induces activation of multiple internal defence mechanisms …

Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and
the metabolic syndrome and appears to contribute to the renal, cardiovascular and …

The association between uric acid (UA) on one side and systemic hypertension (Htn),
dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular …

Substantial evidence suggests that chronic hyperuricemia is an independent risk factor for
hypertension, metabolic syndrome, chronic kidney disease (CKD) and cardiovascular …

In this narrative review, the biological/biochemical impact (toxicity) of a large array of known
individual uremic retention solutes and groups of solutes is summarized. We classified these …

Uric acid is the end product of purine metabolism in humans, and its excessive accumulation
leads to hyperuricemia and urate crystal deposition in tissues including joints and kidneys …