Challenges and opportunities for small molecule aptamer development
M McKeague, MC DeRosa - Journal of nucleic acids, 2012 - Wiley Online Library
Aptamers are single‐stranded oligonucleotides that bind to targets with high affinity and
selectivity. Their use as molecular recognition elements has emerged as a viable approach …
selectivity. Their use as molecular recognition elements has emerged as a viable approach …
Aptamers from random sequence space: Accomplishments, gaps and future considerations
Aptamers are molecular recognition elements made of nucleic acids. Diverse synthetic
aptamers have been discovered in a large number of SELEX experiments since 1990. This …
aptamers have been discovered in a large number of SELEX experiments since 1990. This …
Capillary electrophoresis applied to DNA: determining and harnessing sequence and structure to advance bioanalyses (2009–2014)
BC Durney, CL Crihfield, LA Holland - Analytical and bioanalytical …, 2015 - Springer
This review of capillary electrophoresis methods for DNA analyses covers critical advances
from 2009 to 2014, referencing 184 citations. Separation mechanisms based on free-zone …
from 2009 to 2014, referencing 184 citations. Separation mechanisms based on free-zone …
Analytical methods for kinetic studies of biological interactions: A review
The rates at which biological interactions occur can provide important information
concerning the mechanism and behavior of these processes in living systems. This review …
concerning the mechanism and behavior of these processes in living systems. This review …
How does fluorescent labeling affect the binding kinetics of proteins with intact cells?
Fluorescent labeling is a mainstream technology for detecting molecular binding. Despite
the importance, few studies have been devoted to quantitatively examine the effect of …
the importance, few studies have been devoted to quantitatively examine the effect of …
Analysis of drug interactions with serum proteins and related binding agents by affinity capillary electrophoresis: A review
Biomolecules such as serum proteins can interact with drugs in the body and influence their
pharmaceutical effects. Specific and precise methods that analyze these interactions are …
pharmaceutical effects. Specific and precise methods that analyze these interactions are …
Selective lighting up of epiberberine alkaloid fluorescence by fluorophore-switching aptamer and stoichiometric targeting of human telomeric DNA G-quadruplex …
Aptamers, that exist naturally in living cells as functional elements and can switch
nonfluorescent natural targets to fluorophores, are very useful in developing highly sensitive …
nonfluorescent natural targets to fluorophores, are very useful in developing highly sensitive …
Structure–affinity relationship of the cocaine-binding aptamer with quinine derivatives
S Slavkovic, M Altunisik, O Reinstein… - Bioorganic & Medicinal …, 2015 - Elsevier
In addition to binding its target molecule, cocaine, the cocaine-binding aptamer tightly binds
the alkaloid quinine. In order to understand better how the cocaine-binding aptamer …
the alkaloid quinine. In order to understand better how the cocaine-binding aptamer …
Capillary electrophoresis–based immunoassay and aptamer assay: A review
H Nevídalová, L Michalcová, Z Glatz - Electrophoresis, 2020 - Wiley Online Library
Over the last two decades, the group of techniques called affinity probe CE has been widely
used for the detection and the determination of several types of biomolecules with high …
used for the detection and the determination of several types of biomolecules with high …
Study of molecular interactions by nonequilibrium capillary electrophoresis of equilibrium mixtures: Originations, developments, and applications
L Deng, Q Fu, Y Zhang, F Shui, J Tang, J Wu… - …, 2023 - Wiley Online Library
Molecular interactions play a vital role in regulating various physiological and biochemical
processes in vivo. Kinetic capillary electrophoresis (KCE) is an analytical platform that offers …
processes in vivo. Kinetic capillary electrophoresis (KCE) is an analytical platform that offers …