Exosomes in angiogenesis and anti-angiogenic therapy in cancers
W Olejarz, G Kubiak-Tomaszewska… - International Journal of …, 2020 - mdpi.com
Angiogenesis is the process through which new blood vessels are formed from pre-existing
ones. Exosomes are involved in angiogenesis in cancer progression by transporting …
ones. Exosomes are involved in angiogenesis in cancer progression by transporting …
Resistance mechanisms to anti-angiogenic therapies in cancer
Tumor growth and metastasis rely on tumor vascular network for the adequate supply of
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …
oxygen and nutrients. Tumor angiogenesis relies on a highly complex program of growth …
Molecular mechanism of VEGF and its role in pathological angiogenesis
Over the last seven decades, a significant scientific contribution took place in the delineation
of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of …
of the implications of vascular endothelial‐derived growth factor (VEGF) in the processes of …
Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes
M Robertson-Tessi, RJ Gillies, RA Gatenby… - Cancer research, 2015 - AACR
Histopathologic knowledge that extensive heterogeneity exists between and within tumors
has been confirmed and deepened recently by molecular studies. However, the impact of …
has been confirmed and deepened recently by molecular studies. However, the impact of …
VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2
D Zhao, C Pan, J Sun, C Gilbert, K Drews-Elger… - Oncogene, 2015 - nature.com
Vascular endothelial growth factor-A (VEGF), a potent angiogenic factor, is also implicated in
self-renewal in several normal tissue types. VEGF has been shown to drive malignant stem …
self-renewal in several normal tissue types. VEGF has been shown to drive malignant stem …
Inducing angiogenesis, a key step in cancer vascularization, and treatment approaches
Angiogenesis is a term that describes the formation of new blood and lymphatic vessels from
a pre-existing vasculature. This allows tumour cells to acquire sustenance in the form of …
a pre-existing vasculature. This allows tumour cells to acquire sustenance in the form of …
Angiogenesis inhibitors in cancer therapy: mechanistic perspective on classification and treatment rationales
AE El‐Kenawi, AB El‐Remessy - British journal of …, 2013 - Wiley Online Library
Angiogenesis, a process of new blood vessel formation, is a prerequisite for tumour growth
to supply the proliferating tumour with oxygen and nutrients. The angiogenic process may …
to supply the proliferating tumour with oxygen and nutrients. The angiogenic process may …
Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs
T Hongu, M Pein, J Insua-Rodriguez, E Gutjahr… - Nature cancer, 2022 - nature.com
Disseminated cancer cells frequently lodge near vasculature in secondary organs. However,
our understanding of the cellular crosstalk invoked at perivascular sites is still rudimentary …
our understanding of the cellular crosstalk invoked at perivascular sites is still rudimentary …
Myeloid-derived suppressor cells in cancer patients: a clinical perspective
AJ Montero, CM Diaz-Montero… - Journal of …, 2012 - journals.lww.com
Myeloid-derived suppressor cells (MDSCs) represent a heterogenous collection of immature
myeloid cells endowed with suppressive function on the immune response. Their presence …
myeloid cells endowed with suppressive function on the immune response. Their presence …
Publication of tumor marker research results: the necessity for complete and transparent reporting
LM McShane, DF Hayes - Journal of Clinical Oncology, 2012 - ascopubs.org
Clinical management decisions for patients with cancer are increasingly being guided by
prognostic and predictive markers. Use of these markers should be based on a sufficiently …
prognostic and predictive markers. Use of these markers should be based on a sufficiently …