Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Nanomechanical mapping of soft materials with the atomic force microscope: methods, theory and applications

R Garcia - Chemical Society Reviews, 2020 - pubs.rsc.org
Fast, high-resolution, non-destructive and quantitative characterization methods are needed
to develop materials with tailored properties at the nanoscale or to understand the …

Brillouin microscopy: an emerging tool for mechanobiology

R Prevedel, A Diz-Muñoz, G Ruocco, G Antonacci - Nature methods, 2019 - nature.com
The role and importance of mechanical properties of cells and tissues in cellular function,
development and disease has widely been acknowledged, however standard techniques …

Stiffness sensing by cells

PA Janmey, DA Fletcher… - Physiological …, 2020 - journals.physiology.org
Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Fractional viscoelastic models for power-law materials

A Bonfanti, JL Kaplan, G Charras, A Kabla - Soft Matter, 2020 - pubs.rsc.org
Soft materials often exhibit a distinctive power-law viscoelastic response arising from broad
distribution of time-scales present in their complex internal structure. A promising tool to …

Atomic force microscopy-based force spectroscopy and multiparametric imaging of biomolecular and cellular systems

DJ Müller, AC Dumitru, C Lo Giudice… - Chemical …, 2020 - ACS Publications
During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

Mechanical adaptability of tumor cells in metastasis

V Gensbittel, M Kräter, S Harlepp, I Busnelli, J Guck… - Developmental cell, 2021 - cell.com
The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

A comparison of microfluidic methods for high-throughput cell deformability measurements

M Urbanska, HE Muñoz, J Shaw Bagnall, O Otto… - Nature …, 2020 - nature.com
The mechanical phenotype of a cell is an inherent biophysical marker of its state and
function, with many applications in basic and applied biological research. Microfluidics …

The extracellular matrix viscoelasticity as a regulator of cell and tissue dynamics

A Elosegui-Artola - Current opinion in cell biology, 2021 - Elsevier
The extracellular matrix mechanical properties regulate processes in development, cancer,
and fibrosis. Among the distinct mechanical properties, the vast majority of research has …

Sculpting tissues by phase transitions

PF Lenne, V Trivedi - Nature Communications, 2022 - nature.com
Biological systems display a rich phenomenology of states that resemble the physical states
of matter-solid, liquid and gas. These phases result from the interactions between the …