Emergence, molecular mechanisms and global spread of carbapenem-resistant Acinetobacter baumannii

M Hamidian, SJ Nigro - Microbial genomics, 2019 - microbiologyresearch.org
Acinetobacter baumannii is a nosocomial pathogen that has emerged as a global threat
because of high levels of resistance to many antibiotics, particularly those considered to be …

The current burden of carbapenemases: review of significant properties and dissemination among gram-negative bacteria

D Hammoudi Halat, C Ayoub Moubareck - Antibiotics, 2020 - mdpi.com
Carbapenemases are β-lactamases belonging to different Ambler classes (A, B, D) and can
be encoded by both chromosomal and plasmid-mediated genes. These enzymes represent …

Identification of Klebsiella capsule synthesis loci from whole genome data

KL Wyres, RR Wick, C Gorrie, A Jenney… - Microbial …, 2016 - microbiologyresearch.org
Klebsiella pneumoniae is a growing cause of healthcare-associated infections for which
multi-drug resistance is a concern. Its polysaccharide capsule is a major virulence …

Gastrointestinal Carriage Is a Major Reservoir of Klebsiella pneumoniae Infection in Intensive Care Patients

CL Gorrie, M Mirčeta, RR Wick… - Clinical infectious …, 2017 - academic.oup.com
Background. Klebsiella pneumoniae is an opportunistic pathogen and leading cause of
hospital-associated infections. Intensive care unit (ICU) patients are particularly at risk …

Identification of Acinetobacter baumannii loci for capsular polysaccharide (KL) and lipooligosaccharide outer core (OCL) synthesis in genome assemblies using curated …

KL Wyres, SM Cahill, KE Holt, RM Hall… - Microbial …, 2019 - microbiologyresearch.org
Multiply antibiotic-resistant Acinetobacter baumannii infections are a global public health
concern and accurate tracking of the spread of specific lineages is needed. Variation in the …

Carbapenem-resistant Acinetobacter baumannii: A challenge in the intensive care unit

Y Jiang, Y Ding, Y Wei, C Jian, J Liu… - Frontiers in microbiology, 2022 - frontiersin.org
Carbapenem-resistant Acinetobacter baumannii (CRAB) has become one of the leading
causes of healthcare-associated infections globally, particularly in intensive care units …

Genome-scale rates of evolutionary change in bacteria

S Duchêne, KE Holt, FX Weill, S Le Hello… - Microbial …, 2016 - microbiologyresearch.org
Estimating the rates at which bacterial genomes evolve is critical to understanding major
evolutionary and ecological processes such as disease emergence, long-term host …

Comparative Analysis of the Two Acinetobacter baumannii Multilocus Sequence Typing (MLST) Schemes

S Gaiarsa, G Batisti Biffignandi, EP Esposito… - Frontiers in …, 2019 - frontiersin.org
Acinetobacter species assigned to the Acinetobacter calcoaceticus-baumannii (Acb)
complex, are Gram-negative bacteria responsible for a large number of human infections …

Evolutionary dynamics and genomic features of the Elizabethkingia anophelis 2015 to 2016 Wisconsin outbreak strain

A Perrin, E Larsonneur, AC Nicholson… - Nature …, 2017 - nature.com
An atypically large outbreak of Elizabethkingia anophelis infections occurred in Wisconsin.
Here we show that it was caused by a single strain with thirteen characteristic genomic …

Recent Advances in the Pursuit of an Effective Acinetobacter baumannii Vaccine

PS Gellings, AA Wilkins, LA Morici - Pathogens, 2020 - mdpi.com
Acinetobacter baumannii has been a major cause of nosocomial infections for decades. The
absence of an available vaccine coupled with emerging multidrug resistance has prevented …