Trends in glioblastoma: outcomes over time and type of intervention: a systematic evidence based analysis

L Marenco-Hillembrand, O Wijesekera… - Journal of neuro …, 2020 - Springer
Introduction Despite aggressive treatment with chemoradiotherapy and maximum surgical
resection, survival in patients with glioblastoma (GBM) remains poor. Ongoing efforts are …

Glioblastoma: current status, emerging targets, and recent advances

A Thakur, C Faujdar, R Sharma, S Sharma… - Journal of Medicinal …, 2022 - ACS Publications
Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors

N Hajji, J Garcia-Revilla, MS Soto… - The Journal of …, 2022 - Am Soc Clin Investig
New approaches for the management of glioblastoma (GBM) are an urgent and unmet
clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly …

Identification and characterization of a novel indoleamine 2, 3-dioxygenase 1 protein degrader for glioblastoma

LR Bollu, PV Bommi, PJ Monsen, L Zhai… - Journal of Medicinal …, 2022 - ACS Publications
Indoleamine 2, 3-dioxygenase 1 (IDO1) is a potent immunosuppressive enzyme that inhibits
the antitumor immune response through both tryptophan metabolism and non-enzymatic …

CNS and CNS diseases in relation to their immune system

J Xu, C Ma, M Hua, J Li, Z Xiang, J Wu - Frontiers in Immunology, 2022 - frontiersin.org
The central nervous system is the most important nervous system in vertebrates, which is
responsible for transmitting information to the peripheral nervous system and controlling the …

Global post-marketing safety surveillance of Tumor Treating Fields (TTFields) in patients with high-grade glioma in clinical practice

W Shi, DT Blumenthal, NA Oberheim Bush… - Journal of Neuro …, 2020 - Springer
Abstract Introduction Tumor Treating Fields (TTFields; antimitotic treatment) delivers low-
intensity, intermediate-frequency, alternating electric fields through skin-applied transducer …

Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma

M Li, G Li, J Kiyokawa, Z Tirmizi, LG Richardson… - Acta neuropathologica …, 2020 - Springer
Cancer-associated fibroblasts (CAFs) are activated fibroblasts constituting the major stromal
components in many types of cancer. CAFs contribute to hallmarks of cancer such as …

Tumour immune landscape of paediatric high-grade gliomas

JL Ross, J Velazquez Vega, A Plant, TJ MacDonald… - Brain, 2021 - academic.oup.com
Over the past decade, remarkable progress has been made towards elucidating the origin
and genomic landscape of childhood high-grade brain tumours. It has become evident that …

Cytotoxic screening and antibacterial activity of Withaferin A

A Rossato Viana, B Godoy Noro, JC Lenz… - Journal of Toxicology …, 2022 - Taylor & Francis
Cancer and bacterial infections are among the leading causes of death worldwide. Plant-
derived bioactive compounds constitute promising alternatives for development of new …

Devitalization of glioblastoma cancer cells by non-invasive physical plasma: Modulation of proliferative signalling cascades

S Lehmann, S Bien-Möller, S Marx… - Anticancer …, 2023 - ar.iiarjournals.org
Background/Aim: Glioblastoma (GBM) is the most common and most lethal type of cancer of
the central nervous system in adults. Despite aggressive treatment, which is based on …