8-Hydroxyquinoline and its derivatives have a broad variety of pharmacological properties,
which make them an ideal bioactive building block in the development of metal-based …

The past decade has witnessed a tremendous resurgence in the interest and use of
medicinal plants. The beneficial medicinal effects of plant materials typically result from the …

Screening of small-molecule libraries is an important aspect of probe and drug discovery
science. Numerous authors have suggested that bioactive natural products are attractive …

Organometallic compounds based on bioactive ligand systems have shown promising
antiproliferative properties. The use of 8-hydroxyquinoline and its derivatives as bioactive …

Bromoamination of unfunctionalized olefins was realized under mild conditions using
copper (II) bromide (CuBr2) as both reaction promoter and bromine source. The reactions …

The synthesis of pyrroles has received considerable attention because of their biological
and pharmaceutical activities. Herein we describe a solid-phase multicomponent reaction …

New chiral ligands could be obtained by introducing proline moieties and imidazoline
moieties to binaphthyl skeletons. The chiral ligands exhibited balanced rigidity and flexibility …

The antitubercular drug; para-aminosalicylic acid (PAS) was used as the core scaffold for the
design of a series of 1 H-1, 2, 3-triazolylsalicylhydrazones upon coupling with triazole and …

Aim. DNA-encoded libraries technologies (DELT) are gradually becoming an important part
of standard drug discovery toolbox. DELT is looking to find its place between classic low …

The approaches taken to develop novel metal-based anticancer agents have considerably
changed over the last 50 years since the discovery of the platinum drugs and focus now on …