Impact of the halogen substitution pattern on the biological activity of organoruthenium 8-hydroxyquinoline anticancer agents
M Kubanik, H Holtkamp, T Sohnel… - …, 2015 - ACS Publications
8-Hydroxyquinoline and its derivatives have a broad variety of pharmacological properties,
which make them an ideal bioactive building block in the development of metal-based …
which make them an ideal bioactive building block in the development of metal-based …
[PDF][PDF] Medicinally important phytochemicals: an untapped research avenue
The past decade has witnessed a tremendous resurgence in the interest and use of
medicinal plants. The beneficial medicinal effects of plant materials typically result from the …
medicinal plants. The beneficial medicinal effects of plant materials typically result from the …
Probing chemical space with alkaloid-inspired libraries
Screening of small-molecule libraries is an important aspect of probe and drug discovery
science. Numerous authors have suggested that bioactive natural products are attractive …
science. Numerous authors have suggested that bioactive natural products are attractive …
Hydroxyquinoline-derived anticancer organometallics: Introduction of amphiphilic PTA as an ancillary ligand increases their aqueous solubility
Organometallic compounds based on bioactive ligand systems have shown promising
antiproliferative properties. The use of 8-hydroxyquinoline and its derivatives as bioactive …
antiproliferative properties. The use of 8-hydroxyquinoline and its derivatives as bioactive …
Regioselective Copper (II)‐Mediated Bromoamination of Unfunctionalized Olefins: An Efficient Route to N‐Heterocyclic Compounds
GQ Liu, ZY Ding, L Zhang, TT Li, L Li… - … Synthesis & Catalysis, 2014 - Wiley Online Library
Bromoamination of unfunctionalized olefins was realized under mild conditions using
copper (II) bromide (CuBr2) as both reaction promoter and bromine source. The reactions …
copper (II) bromide (CuBr2) as both reaction promoter and bromine source. The reactions …
Solid-phase synthesis of pyrrole derivatives through a multicomponent reaction involving Lys-containing peptides
YE Jad, SK Gudimella, T Govender… - ACS Combinatorial …, 2018 - ACS Publications
The synthesis of pyrroles has received considerable attention because of their biological
and pharmaceutical activities. Herein we describe a solid-phase multicomponent reaction …
and pharmaceutical activities. Herein we describe a solid-phase multicomponent reaction …
Cu (II)‐Catalyzed Enantioselective Aza‐Friedel‐Crafts Reaction of 1‐Naphthols and Electron‐Rich Phenols with Isatin‐Derived Ketimines
Q Cai, T Yu, J Li, Y Zhao, J Hou, L Xue… - … A European Journal, 2024 - Wiley Online Library
New chiral ligands could be obtained by introducing proline moieties and imidazoline
moieties to binaphthyl skeletons. The chiral ligands exhibited balanced rigidity and flexibility …
moieties to binaphthyl skeletons. The chiral ligands exhibited balanced rigidity and flexibility …
Synthesis and anti-mycobacterial activity of 4-(4-phenyl-1H-1,2,3-triazol-1-yl)salicylhydrazones: revitalizing an old drug
HHM Abdu-Allah, BGM Youssif… - Archives of pharmacal …, 2017 - Springer
The antitubercular drug; para-aminosalicylic acid (PAS) was used as the core scaffold for the
design of a series of 1 H-1, 2, 3-triazolylsalicylhydrazones upon coupling with triazole and …
design of a series of 1 H-1, 2, 3-triazolylsalicylhydrazones upon coupling with triazole and …
[PDF][PDF] Heterocyclization vs Coupling Reactions: A DNA-Encoded Libraries Case
OV Oksiuta, AE Pashenko, RV Smalii… - Journal of Organic and …, 2023 - core.ac.uk
Aim. DNA-encoded libraries technologies (DELT) are gradually becoming an important part
of standard drug discovery toolbox. DELT is looking to find its place between classic low …
of standard drug discovery toolbox. DELT is looking to find its place between classic low …
[HTML][HTML] A multifaceted approach towards organometallic anticancer agent development
CG Hartinger - Journal of Organometallic Chemistry, 2024 - Elsevier
The approaches taken to develop novel metal-based anticancer agents have considerably
changed over the last 50 years since the discovery of the platinum drugs and focus now on …
changed over the last 50 years since the discovery of the platinum drugs and focus now on …