Intracerebral haemorrhage (ICH) is a dramatic condition caused by the rupture of a cerebral
vessel and the entry of blood into the brain parenchyma. ICH is a major contributor to stroke …

The blood–brain barrier (BBB) is a continuous endothelial membrane within brain
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …

Background Cerebral amyloid angiopathy (CAA) is an age-related small vessel disease,
characterised pathologically by progressive deposition of amyloid β in the cerebrovascular …

Intravenous thrombolysis is the only approved systemic reperfusion treatment for patients
with acute ischaemic stroke. These European Stroke Organisation (ESO) guidelines provide …

Few studies have focused on the connection between glymphatic dysfunction and cerebral
small vessel disease (CSVD), partially due to the lack of non-invasive methods to measure …

Cerebral amyloid angiopathy, which is defined by cerebrovascular deposition of amyloid β,
is a common age-related small vessel pathology associated with intracerebral haemorrhage …

492 Stroke February 2018 lobar hemorrhages required for probable CAA, or alternatively
preclude probable CAA if in deep territories. The rationale for counting all types of …

Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …

Cerebral microbleeds (CMBs) are small haemorrhages nearby blood vessels. They have
been recognized as important diagnostic biomarkers for many cerebrovascular diseases …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …