Activation of the p53 signaling pathway by DNA‐damaging agents was originally proposed
to result either in cell cycle checkpoint activation to promote survival or in apoptotic cell …

Based on its potent capacity to induce tumor cell death and to abrogate clonogenic survival,
radiotherapy is a key part of multimodal cancer treatment approaches. Numerous clinical …

The induction of tumor cell death is one of the major goals of radiotherapy and has been
considered to be the central determinant of its therapeutic outcome for a long time. However …

Evasion of DNA damage-induced cell death, via mutation of the p53 tumor suppressor or
overexpression of prosurvival Bcl-2 family proteins, is a key step toward malignant …

Aims Cardiotoxicity by doxorubicin predicts worse prognosis of patients. Accumulation of
damaged DNA has been implicated in doxorubicin-induced cardiotoxicity. SIRT1, an NAD+ …

Radioresistance and limitation of irradiative dosage usually lead to failure in depletion of
hypoxic tumors. Herein we developed multifunctional mesoporous silica nanoparticles …

Radiation damage to biological systems is determined by the type of radiation, the total
dosage of exposure, the dose rate, and the region of the body exposed. Three modes of cell …

Radiation exposure induces cell and tissue damage, causing local and systemic
inflammatory responses. Because the inflammasome pathway is triggered by cell death and …

The average survival of patients with glioblastoma is 12–15 months. Therefore, finding a
new treatment method is important, especially in cases that show resistance to treatment …

Malignant brain tumors remain a major cause of concern and mortality as successful
treatment is hindered due to the poor transport and low penetration of chemotherapeutics …