Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

The transcriptional termination of unstable non-coding RNAs (ncRNAs) is poorly understood
compared to coding transcripts. We recently identified ZC3H4-WDR82 (" restrictor") as …

Cancer genome sequencing consortiums have recently catalogued an abundance of
somatic mutations, across a wide range of human cancers, in the chromatin-modifying …

Promoter-proximal pausing by RNA Pol II is a rate-determining step in gene transcription
that is hypothesized to be a prominent point at which regulatory factors act. The pausing …

The polymerase-associated factor 1 complex (PAF1C) is a key, post-initiation transcriptional
regulator of both promoter-proximal pausing and productive elongation catalyzed by RNA …

MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier
that regulates almost every physiological process in a cell including cell cycle, proliferation …

Abstract The Paf1 complex (Paf1C) is a conserved transcription elongation factor that
regulates transcription elongation efficiency, facilitates co-transcriptional histone …

Transcription elongation requires elaborate coordination between the transcriptional
machinery and chromatin regulatory factors to successfully produce RNA while preserving …

Metazoan gene expression regulation involves pausing of RNA polymerase (Pol II) in the
promoter-proximal region of genes and is stabilized by DSIF and NELF. Upon depletion of …